Abstract: Objective To explore the relationship between serum heart-type fatty acid binding protein （H-FABP） level and cardiac function parameters in the patients with acute myocardial infarction （AMI）.Methods Patients with AMI treated in a hospital in Zigong City from May 2015 to May 2017 were selected as the case group and individuals without cardiovascular disease who underwent a physical examination at the same hospital as the control group. H-FABP and major cardiac function indexes were analyzed at different time points and compared between the two groups.Results A total of 124 patients with AMI and 124 healthy people without cardiovascular disease were enrolled in this study, including 69 males and 55 females in the case group and the same in the control group. There were no significant differences in mean age and BMI between the two groups （P>0.05 for both）. The difference of H-FABP between the two groups at different time points （2, 4, 8, 12, 24 h） was statistically significant （P<0.01）. H-FABP gradually increased before 8 h, reached a maximum at 8 h, and then gradually decreased. The H-FABP concentration in the case group was higher than that in the control group at each time point （all P<0.01）. The LVEF, LVEDd and FMD were lower in the case group than those in the control group at 8 h after onset （P<0.01）, and EMCs was higher than that in the control group （P<0.01）. There were 43, 39, and 42 cases of Killip grades at levels II, III, and IV, accounting for 34.7%, 31.5%, and 33.9%, respectively. The higher the grade, the higher the detection value of H-FABP, LVEDd and EMCs, the lower the LVEF and FMD detection values （P<0.01）. Serum H-FABP levels were negatively correlated with LVEF and FMD levels （b=-2.764, -2.846）, and positively correlated with EMCs and LVEDd levels （b=2.294, 2.495）.Conclusion H-FABP has good correlation with cardiac function parameters in patients with AMI and can be used as an index for evaluation of early cardiac function.

Key words: Acute myocardial infarction, Heart type fatty acid binding protein, Cardiac function