Abstract: Objective To investigate the status of electronic health （e-Health） literacy among college students in Guangdong Province during the COVID-19 epidemic, and to explore the influencing factors, so as to provide a basis for further improving the e-Health literacy of college students. Methods Web-based questionnaire survey was used among college students in Guangdong Province. Results A total of 16 497 valid questionnaires were collected,including 11 268 girls（68.3%）.There were 7 241 students （43.9%）, 4 467 students （27.1%）, 2 842 students （17.2%） and 1 947 students （11.8%） in freshmen, sophomore, junior and seniors respectively, with 5 769 students （35.0%） in liberal arts among all disciplines.The average score of e-Health literacy was （29.62±6.74）, with a qualified rate of 23.6%. Multivariate analysis showed that the students having higher e-Health literacy were medical majored（β’=0.053）, currently in Guangzhou or Shenzhen（β’=0.030）, having more information sources（β’=0.037）, having more approaches to judge the reliability of online information （β’=0.034）,having more concern about COVID-19-associated information（β’=0.118）,having more knowledge of COVID-19（β’=0.233）; And the students having lower e-Health literacy were female（β’=-0.039）,the more the confusion caused by pandemic-related information（β’=-0.069）. Conclusion E-Health literacy ability of college students in Guangdong Province is relatively low. Improving e-Health literacy can not only improve their ability of judging and acquiring health information, but also raise the awareness of the epidemic.

Key words: College students, e-Health literacy, Health information, Health promotion