Abstract: Objective To comprehensively investigate the progress, hotspots and frontiers of Monkeypox virus (MPXV) over the past decade through bibliometric methods. Methods Publications related to MPXV from 2015 to 2024 were retrieved from the Web of Science Core Collection. CiteSpace 6.2.R3 was employed to conduct a visual analysis of publication outputs, institutions, authors, and keywords. Results A total of 2 265 articles were included. Prior to 2022, research output remained limited; however, a surge in publications occurred following 2022, reflecting heightened global scholarly attention. The Centers for Disease Control and Prevention (CDC) in the United States (151 publications) emerged as the most prolific institution, while University College London exhibited the highest citation impact (73.09 citations per article). Mccollum AM (49 publications) from the United States was the most productive author. High-frequency keywords included "Monkeypox virus" "public health" "men who have sex with men (MSM)" "molecular docking" and "deep learning". Keyword clustering analysis identified 12 distinct clusters. Burst detection revealed emerging terms such as "global health" and "computational modeling, " highlighting the increasing integration of information technology in MPXV research. Conclusions Current research on MPXV has expanded rapidly, yet collaboration among authors and institutions remains limited, with no dominant core research network yet established. Research hotspots primarily focus on epidemiological characteristics, infectious disease modeling, vaccine development, and applications of information technology, particularly in the development of high-reliability diagnostic assays, vaccines, and antiviral therapeutics.

Key words: Monkeypox Virus, CiteSpace, Web of Science, Visual Analysis, Bibliometrics