Abstract: Objective To understand the epidemiological characteristics of HIV/AIDS in Guangxi from 2009 to 2011, and to provide the scientific evidence for developing prevention and control strategies. Methods The accumulative data of reported HIV/AIDS cases by the end of 2009, 2010, and 2011, were downloaded from HIV/AIDS comprehensive prevention and control information system database. Statistical analysis of the epidemic information of the data was performed. Results A total of 36 669 HIV/AIDS cases were reported in Guangxi from 2009 to 2011, including 23 893 HIV infection cases (65.2%) and 12 776 AIDS cases (34.8%). Of them, 24 599 cases were male and 12 070, female. 24 095 cases were peasants (65.7%). The cases at 20-39 age group [JP2]accounted for the largest proportion, but was decreasing year by year, from 57.7% (43 660/75 716) in 2009 down to 36.1% (5 150/14 250) in 2011; cases at 60 years and above increased obviously to 28.4% (4 052/14 250）in 2011 from 18.7% (2 012/10 771）[JP]in 2009; the married accounted for 64.5%（23 664/36 669）, of whom, 52.4% （12 406/23 664）received partner testing with a testing positive rate of 56.0%（6 946/12 406）. Heterosexual transmission was the main transmission mode, accounting for 90.0%（12 821/14 250） of all in 2011. Most of men and women under the age of 40 years old had extramarital heterosexual contact history, and the proportion was 74.6% (18 998/25 466) and 60.5% (3 737/6 179) respectively; women over 40 years old were mainly infected by their HIV positive spouse, with the proportion of 52.4%（2 633/5 023）. From 2009 to 2011, 9 282 AIDS patients were died, including 4 471 death reported in the same year, accounting for 12.2% （4 471/36 669）of new reported cases, and 48.2% （4 471/9 282）of the deaths report in that year. Conclusion New reported HIV/AIDS cases and died cases showed a rising trend in Guangxi from 2009 to 2011, the place distribution of HIV cases was various in counties; heterosexual sex transmission route was the main one; the proportion of infected cases in the middle and older age group increased sharply; the problem of finding patients late is more serious. We should strengthen the surveillance of high-risk and key groups, find and treat the cases early, and conduct effective intervention into different groups to reduce new infections and mortality.