Abstract: ObjectiveTo investigate prevalence of selfreported lipoprotein metabolic disorder and related risk factors among residents aged ≥15 years old in Guangzhou so as to provide a scientific basis for early prevention and intervention of cardiovascular and cerebrovascular diseases.MethodsUsing multistage cluster random sampling method, residents aged 15 years and older were selected from 9 600 households in Guangzhou for questionnaire survey and physical examination. Contents of the questionnaire included the general information, daily life, lipoprotein metabolic disorder, and other common chronic diseases. Items of physical examination included height, weight, waist, hip circumference, and blood pressure. Univariate and multivariate logistic regressions were used to analyze the risk factors of the diseases among different groups.ResultsA total of 23 994 residents aged 15 years and older were investigated. The male to female ratio was 1∶1.03. They were concentrated in the group aged 35-44 years (20.3%); their education levels were mainly junior, senior or secondary school (54.2%) and the occupation was mainly the unemployed(21.7%). The total prevalence of selfreported lipoprotein metabolic disorder was 1.47% (352/23 994). Multivariate logistic regression analysis showed that age 55-65 years (OR=1.34), high school/technical secondary school and college or above (OR=2.37, 3.17), retirees (OR=2.65), newly or ever diagnosed hypertension (OR=1.54, 5.26), diabetes mellitus (OR=2.33), and abnormal BMI (OR=2.78-10.33) were independent risk factors for lipoprotein metabolic disorder, while age groups at 25-34, 35-44 years old (OR=0.13,0.46) and fruit intake ≥200 g/d (OR=0.77) were protective factors for lipoprotein metabolic disorder (P<0.05 or P＜0.01).ConclusionThe total prevalence of selfreported lipoprotein metabolic disorder was low in Guangzhou. Each community should strengthen the high risk population screening and improve the awareness of the disease. Reasonable dietary pattern, weight control, and prevention of hypertension and diabetes were important measures to prevent and control lipoprotein metabolic disorder.