Abstract: ObjectiveTo analyze the prevelant trend in incidence of breast cancer in Guangzhou during 2004-2011.MethodsThe incidence rates of breast cancer were calculated by analyzing data obtained from Guangzhou Cancer Registration Center. Standardized rates were calculated using the Segi's world standard population. Jointpoint Regression Program (4.2.0.2) was used to calculate the annual percentage change (APC). ResultsA total of 14 279 new cases of breast cancer were registered in Guangzhou City from 2004 to 2011. The crude incidence of breast cancer increased from 46.29/100 000 population in 2004 to 51.49/100 000 in 2011, increasing by 11.23%, and the APC was 1.62% (95％CI: 0.30％-2.90％). Two peaks in the incidence of breast cancer were observed, the first peak in the 50-64 year age group and the second in the 70-74 year age group, and the peak before menopause was obviously higher than that after menopause. APCs were 2.99％ (95％CI:0.01％-6.01％) in the age group 55-59 years and 4.36％ (95％CI:2.15％-6.53％) in the age group 75-79 years. ConclusionThe incidence of breast cancer in Guangzhou increased at a faster rate. The prevention and control of breast cancer should be strengthened.