2010—2021年广州市初治HIV感染者糖脂代谢异常患病趋势及其年龄-时期-队列模型分析

doi:10.12183/j.scjpm.2024.0246

华南预防医学 ›› 2024, Vol. 50 ›› Issue (3): 246-250.doi: 10.12183/j.scjpm.2024.0246

2010—2021年广州市初治HIV感染者糖脂代谢异常患病趋势及其年龄-时期-队列模型分析

尚萌琳¹, 谢今朝¹, 王旭¹, 刘聪², 钟海丹², 杜佩珊², 李全敏², 蔡卫平², 李凌华², 顾菁¹

1.中山大学公共卫生学院,广东广州 510000;
2.广州市第八人民医院感染病中心

收稿日期:2023-11-13 出版日期:2024-03-20 发布日期:2024-04-22
通讯作者: 顾菁,E-mail：gujing5@mail.sysu.edu.cn
作者简介:尚萌琳（1998—），女，在读硕士研究生，研究方向：流行病与卫生统计学
基金资助:
“十三五”国家科技重大专项（2018ZX10715004）

Trends in abnormal glucose and lipid metabolism among newly treated HIV-infected patients and age-period-cohort model analysis in Guangzhou,2010-2021

SHANG Menglin¹, XIE Jinzhao¹, WANG Xu¹, LIU Cong², ZHONG Haidan², DU Peishan², LI Quanmin², CAI Weiping², LI Linghua², GU Jing¹

1. School of Public Health,Sun Yat-sen University,Guangzhou 510000,China;
2. Infectious Disease Center,Guangzhou Eighth People's Hospital

Received:2023-11-13 Online:2024-03-20 Published:2024-04-22

摘要/Abstract

摘要： 目的分析2010—2021年广州市初治HIV感染者糖脂代谢异常患病率的变化,探讨性别、年龄、时期、队列因素的影响。方法基于广州市第八人民医院2010—2021年16 454例初治HIV感染者数据,采用Joinpoint回归模型分析糖代谢异常、甘油三酯代谢异常、胆固醇代谢异常的患病率变化趋势,采用年龄-时期-队列模型分析患病率变化的影响因素。结果 16 454例初治HIV感染者中,平均年龄（36.78±12.07）岁,男性13 783例（83.8%）。2010—2021年期间初治HIV感染者糖代谢异常（AAPC=-2.4%,95% CI：-5.31%~0.50%,P=0.103）、甘油三酯代谢异常（APC=AAPC=-4.13%,95% CI：-7.59%~-0.54%,P=0.029）、胆固醇代谢异常（APC=AAPC=-13.47%,95% CI：-16.03%~-10.84%,P<0.001）患病率整体均呈下降趋势,女性脂代谢异常患病率高于男性。年龄-时期-队列模型结果显示,糖代谢异常、甘油三酯代谢异常的患病率在40~50岁最高,胆固醇代谢异常患病率随年龄增大逐渐下降;糖脂代谢异常的患病率随时期整体呈下降趋势;较早出生队列的人群糖脂代谢异常的患病率较高。结论近年来初治HIV感染者糖脂代谢异常负担整体降低,但仍应加强对糖代谢异常的防控。女性、中老年群体、较早的感染者是糖脂代谢异常的高危群体。

关键词: 抗病毒治疗, HIV, 糖脂代谢异常, Joinpoint回归模型, 年龄-时期-队列模型

Abstract: Objective To analyze the changes in the prevalence of abnormal glucose and lipid metabolism among newly treated HIV-infected patients in Guangzhou from 2010 to 2021,and explore the influence of gender,age,period,and cohort factors. Methods Based on the treatment data of 16 454 newly treated HIV-infected patients at Guangzhou Eighth People's Hospital from 2010 to 2021,the trends in the prevalence of abnormal glucose,triglyceride,and cholesterol metabolism were analyzed by using Joinpoint regression,and the influencing factors of prevalence change were analyzed by using age-period-cohort model. Results Among the 16 454 newly treated HIV-infected patients,the mean age was （36.78±12.07） years old,and 13 783 （83.8%） were males. From 2010 to 2021,the prevalence of abnormal glucose metabolism （AAPC=-2.4%,95% CI：-5.31% - 0.50%,P=0.103）,abnormal triglyceride metabolism （APC=AAPC=-4.13%,95% CI：-7.59% - -0.54%,P=0.029）,and abnormal cholesterol metabolism （APC=AAPC= -13.47%,95% CI：-16.03% - -10.84%,P < 0.001） showed a downward trend. The prevalence of abnormal lipid metabolism in females was higher than that in males. The results of the age-period-cohort model showed that the prevalence of abnormal glucose metabolism and triglyceride metabolism was highest in the age of 40-50 years,the prevalence of abnormal cholesterol metabolism gradually declined with age; the prevalence of abnormal glucose and lipid metabolism showed an overall decreasing trend with the period; and the prevalence of abnormal glucose and lipid metabolism was higher in the population of the earlier birth cohort. Conclusions The overall burden of abnormal glucose and lipid metabolism among newly treated HIV-infected patients has decreased in recent years. However,there is a need to enhance the prevention and control measures for abnormal glucose metabolism. Females,middle-aged and older groups,and earlier infected individuals are at high risk for abnormal glucose and lipid metabolism.

Key words: Antiretroviral therapy, HIV, Abnormal glucose and lipid metabolism, Joinpoint regression model, Age-period-cohort model

中图分类号:

R195.4

尚萌琳, 谢今朝, 王旭, 刘聪, 钟海丹, 杜佩珊, 李全敏, 蔡卫平, 李凌华, 顾菁. 2010—2021年广州市初治HIV感染者糖脂代谢异常患病趋势及其年龄-时期-队列模型分析[J]. 华南预防医学, 2024, 50(3): 246-250.

SHANG Menglin, XIE Jinzhao, WANG Xu, LIU Cong, ZHONG Haidan, DU Peishan, LI Quanmin, CAI Weiping, LI Linghua, GU Jing. Trends in abnormal glucose and lipid metabolism among newly treated HIV-infected patients and age-period-cohort model analysis in Guangzhou,2010-2021[J]. South China Journal of Preventive Medicine, 2024, 50(3): 246-250.

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2010—2021年广州市初治HIV感染者糖脂代谢异常患病趋势及其年龄-时期-队列模型分析

Trends in abnormal glucose and lipid metabolism among newly treated HIV-infected patients and age-period-cohort model analysis in Guangzhou,2010-2021

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