华南预防医学 ›› 2014, Vol. 40 ›› Issue (2): 137-143.doi: 10.13217/j.scjpm.2014.0137

• 论著 • 上一篇    下一篇

广东省2011—2012年疑似预防接种异常反应监测数据分析

赵占杰,刘隽,郑慧贞,梁剑,谢莘,刘宇,邵晓萍   

  1. 广东省疾病预防控制中心,广东 广州 511430
  • 收稿日期:2013-10-18 出版日期:2014-04-20 发布日期:2014-04-22
  • 作者简介:赵占杰(1970—),男,在职硕士研究生,副主任医师,主要从事疑似预防接种异常反应监测、调查诊断、补偿,疫苗针对传染病监测等工作

Adverse events following immunization surveillance in Guangdong Province, 2011—2012

ZHAO Zhan-jie, LIU Jun, ZHENG Hui-zhen,LIANG Jian, XIE Xin, LIU Yu, SHAO Xiao-ping.   

  1. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China
  • Received:2013-10-18 Online:2014-04-20 Published:2014-04-22

摘要: 目的 分析广东省2011—2012年疑似预防接种异常反应(AEFI)的发生特征,评价AEFI信息管理系统运转情况及预防接种安全性。方法 通过全国AEFI信息管理系统收集2011年1月1日至2012年12月31日报告的AEFI个案数据,通过广东省疫苗月报告系统收集同期全省疫苗接种数据,采用描述性流行病学方法对AEFI发生特征进行流行病学分析。结果 2011—2012年广东省共报告AEFI个案9 753例(报告发生率为8 977/100万剂次),男、女性分别5 945、3 808例;以≤1岁、2~7岁人群为主,分别占65.75%(6 413/9 753)、32.29%(3 149/9 753)。一般反应6 211例(63.68%,6 211/9 753),其平均报告发生率为5 717/100万剂次,以发热、红肿、硬结为主;异常反应2 969例(30.44%,2 969/9 753),平均报告发生率为27.33/100万剂次,以过敏性皮疹(2 399例)、卡介苗淋巴结炎(137例)和血管性水肿(125例)为主,共占89.63%(2 661/2 969),其中严重异常反应193例(1.98%,193/9 753),平均报告发生率为1.79/100万剂次,以过敏性休克(57例)、血小板减少性紫癜(20例)和过敏性紫癜(16例)为主, 共占48.19%(93/193)。87.41%(8 525/9 753)AEFI个案发生在接种后当天或第2天,治愈和好转占97.75%(9 534/9 753)。异常反应调查诊断结论 92.49%(2 746/2 969)由疾控机构调查组作出,89.59%(2 660/2 969)由县级机构作出。结论 广东省AEFI监测敏感度较高,AFEI常发生在小年龄组和接种后当天或第2天,预后良好。

Abstract: Methods Residents in cities of Guangzhou and Zhaoqing were selected by stratified random sampling method.Intercept on street and face to face household questionnaire surveys were conducted to investigate the participants' demographic characteristics, such as gender, age, birthplace, education, and their understanding on property and ingredients of herbal tea, the drinking status and habits.Descriptive epidemiological analysis was applied, and univariate and multivariate logistic regressions were used to determine the factors influencing herbal tea drinking habit.Results A total of 2 154 residents were recruited.Of them, 1005 (46.7%) were from Guangzhou and 1149 (53.3%) from Zhaoqing; 957 (44.4%) were males and 1 197 (55.6%) females; 522 (24.2%) were aged 12-19 years.Birth place of 1.781 (82.7%) participants was Guangdong.Among all the participants, 98.7% knew one or more kinds of herbal tea, 43.7% knew six or more components of the herbal tea, 49.2% considered the herbal tea to be Chinese herbal medicine, 99.1% once drank herbal tea, and 37.6% had a habit of drinking herbal tea.Multivariate logistic regression showed that those aged 30-39(OR=1.47),40-49(OR=1.58),and aged 50 and above(OR=1.78), birth place of Guangdong (OR=2.92), currently living in Guangzhou (OR=2.97), knowing 1 to 5 kinds of herbal tea (OR=2.28), knowing 6 or more ingredients of herbal tea tended to have a habit of drinking herbal tea (P<0.05 or P<0.01).Conclusion Acceptance of herbal tea was high in residents of Guangzhou and Zhaoqing cities.Age, birthplace, living place, and understanding of herbal tea ingredients were factors that would influence the behavior of drinking herbal tea.

中图分类号: 

  • R186