Abstract: Objective To investigate prevalence, knowledge, attitudes, and practices (KAP) of chronic diseases among residents in Liurong Community, and to provide scientific basis for developing effective community prevention and control measures of chronic diseases. Methods The data of household survey of Liurong Community were sourced from the Guangzhou Community Health Diagnosis in 2009.One hundred households per resident committee from 8 resident committees in all resident committees of Liurong Community were randomly selected.Residents were interviewed with a standardized questionnaire including demographic characteristics, family status, chronic diseases and behavioral risk factors, and other related diseases.The KAP contents were answered by subjects aged 15 years and over.Results A total of 2 252 people (1 090 males and 1 162 females) aged from 12 to 85 years were investigated.The overall chronic diseases prevalence was 30.91% (696/2 252) and the standardized prevalence was 22.83%.Among residents aged 65 and over, the prevalence and standardized prevalence were 71.95% (413/574) and 54.08%, respectively.The trend in the prevalence of chronic diseases was strongly associated with the increasing of age (P＜0.01).The top five chronic diseases with high prevalence were: hypertension (19.63%，442/2 252), diabetes (6.08%, 137/2 252), coronary heart disease (2.40%, 54/2 252), hyperlipidemia (1.82%, 41/2 252), and stroke (1.55%, 35/2 252).The KAP survey results showed that the rates of behavior for patients with chronic diseases and non-chronic diseases to participating in health knowledge lectures in community were 16.67% (115/690) and 8.84% (118/1 335), respectively, (P<0.01); the awareness rate of hypertension related knowledge of patients with chronic diseases was higher than that of patients with non-chronic diseases (P＜0.01); the rates of self-awareness of hypertension, self-monitoring, and behavior often taking the initiative to acquire health knowledge in patients with chronic diseases were higher than those in non-chronic diseases patients (P＜0.01 for all).The rates of behaviors of unhealthy lifestyle such as smoking and lack of physical exercise among patients with non-chronic diseases were higher than those among patients chronic ones, while the smoking quit rate was significantly higher in patients with chronic diseases than that in those with non-chronic diseases (P＜0.01 for all).Conclusion There was a high prevalence rate of chronic diseases among residents in Liurong Community.Residents would tend to pay attention to control risk factors after suffering from chronic diseases.The chronic disease prevention and control strategies should be extended to healthy population, and the awareness of whole population should be improved.