炎症性肠病老年患者血清25-羟维生素D及维生素D1-α-羟化酶水平相关性

doi:10.13217/j.scjpm.2019.0319

摘要/Abstract

摘要： 目的探讨老年炎症性肠病（IBD）患者血清25-羧维生素D与维生素D1-α羟化酶（CYP27B1）表达水平及其与疾病严重程度的相关性。方法以自贡市第四人民医院消化内科于2015—2018年期间诊治的所有≥60岁IBD患者为研究对象,选择同时期进行健康体检的老年人作为对照组。对病例组和对照组血清25-羟维生素D水平及CYP27B1的表达情况进行分析。结果本研究共纳入IBD老年患者93例,男性58例,女性35例,平均年龄（64.7 ± 5.1）岁,对照组50人,男性31人,女性19人,平均年龄（63.7 ± 4.8）岁,病例组和对照组平均年龄及性别构成差异均无统计学意义（均P>0.05）。病例明确诊断为溃疡性结肠炎（UC）的48例,克罗恩病（CD ）45例。UC、CD和对照组的25-羟维生素D检测值分别为（11.06 ± 4.14）、（12.51 ± 4.77）、（16.26 ± 5.23）ng/mL,CYP27B1表达IHC评分分别为（9.5 ± 1.1）、（9.3 ± 1.3）、（3.4 ± 0.6）,差异均有统计学意义（均P<0.01）。2组患者25-羟维生素D水平与疾病活动程度评分均呈负相关关系（r=-0.325、-0.382）,CYP27B1表达IHC评分均与疾病活动度评分呈正相关关系（r=0.413、0.371）。结论老年IBD患者中血清25-羧维生素D水平显著低于正常人群,而CYP27B1表达高于正常人群,并与病情的严重程度相关。

关键词: 炎症性肠病, 25-羧维生素D, 维生素D1-羟化酶, 老年患者

Abstract: Objective To measure serum 25-carboxyvitamin D levels and vitamin D1-α-hydroxylase （CYP27B1） expression levels in elderly patients with inflammatory bowel disease （IBD） and their correlation with the severity of the disease. Methods All patients aged ≥60 years, diagnosed with IBD and treated in the Department of Gastroenterology, the Fourth People‘s Hospital of Zigong City from 2015 to 2018 were included in the study. The elderly people who underwent physical examination at the same period were selected as the control group. Serum 25-hydroxyvitamin D levels and CYP27B1 expression of the two groups were analyzed. Results Ninety-three elderly patients with IBD were enrolled in the study, including 58 males and 35 females, with an average age of （64.7 ± 5.1） years. Fifty persons were selected in the control group, including 31 males and 19 females, with an average age of （63.7 ± 4.8） years. There were no significant differences in mean age and gender composition between the two groups （P>0.05 for both）.Forty-eight patients were diagnosed with ulcerative colitis （UC） and 45, with Crohn’s disease （CD）. Levels of 25-hydroxyvitamin D in patients with UC, patients with CD and control group were （11.06 ± 4.14）, （12.51 ± 4.77）, （16.26 ± 5.23） ng/mL, respectively, and the IHC scores of CYP27B1 expression were （9.5 ± 1.1）, （9.3 ± 1.3）, and （3.4 ± 0.6）, respectively （P<0.01 for all）. A negative correlation was observed between the level of 25-hydroxyvitamin D and the disease activity score （r=-0.325, -0.382）, while the IHC score of YP27B1 was positively correlated with the disease activity score （r=0.413, 0.371）. Conclusion Serum 25-carboxy vitamin D level in elderly IBD patients was significantly lower than that in normal population, while CYP27B1 expression was higher than that in normal population and correlated with the severity of the disease.

Key words: Inflammatory bowel disease, 25-carboxy vitamin D, Vitamin D1-hydroxylase, Elderly patients

中图分类号:

R151.4

宋自阆, 兰培相. 炎症性肠病老年患者血清25-羟维生素D及维生素D1-α-羟化酶水平相关性[J]. 华南预防医学, 2019, 45(4): 319-322.

SONG Zi-lang, LAN Pei-xiang. Serum levels of 25-carboxyvitamin D and vitamin D1-α-hydroxylase in elderly patients with inflammatory bowel disease[J]. South China Journal of Preventive Medicine, 2019, 45(4): 319-322.

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