心型脂肪酸结合蛋白对急性心肌梗死患者早期心功能参数评价价值

doi:10.13217/j.scjpm.2019.0436

华南预防医学 ›› 2019, Vol. 45 ›› Issue (5): 436-439.doi: 10.13217/j.scjpm.2019.0436

心型脂肪酸结合蛋白对急性心肌梗死患者早期心功能参数评价价值

徐晓玲¹, 殷明刚²

1.自贡市第三人民医院,四川自贡 643020;
2.自贡市第一人民医院

收稿日期:2019-06-20 出版日期:2019-10-20 发布日期:2019-10-20
通讯作者: 殷明刚,E-mail：ymg1973@163.com
作者简介:徐晓玲（1966—）,女,大学本科,副主任技师,研究方向：输血检验
基金资助:
四川省卫生和计划生育科研项目（17PJ526）

Value of heart-type fatty acid binding protein in evaluating early cardiac function parameters in patients with acute myocardial infarction

XU Xiao-ling¹, YIN Ming-gang²

1.The Third People’s Hospital of Zigong, Zigong 643020,China;
2.The First People’s Hospital of Zigong;

Received:2019-06-20 Online:2019-10-20 Published:2019-10-20

摘要/Abstract

摘要： 目的探讨血清心型脂肪酸结合蛋白（H-FABP）水平与急性心肌梗死（AMI）患者部分心功能指标的相关性,为预防及早期发现急性心肌梗死提供依据。方法以2015年5月至2017年5月在自贡市某医院进行治疗的AMI患者作为研究对象病例组,并以在同医院进行健康体检的无心血管疾病人群为对照组,对病例组发病后不同时间点和对照组人群H-FABP及主要心功能指标进行分析。结果本研究共对124例AMI病例及124名无心血管疾病的健康体检者进行研究,2组人群男、女分别为69、55例,平均年龄和BMI差异均无统计学意义（均P>0.05）。发病后不同时间点（2、4、8、12、24 h）病例组H-FABP检测结果差异有统计学意义（P<0.01）,H-FABP在8 h前逐渐上升,于8 h达到最大值,其后逐渐降低。病例组在各时间点的H-FABP浓度均高于对照组（均P<0.01）。病例组发病后8 h时的左室射血分数（LVEF）、左室舒张未期内径（LVEDd）、血管舒张功能（FMD）均低于对照组（均P<0.01）,内皮细胞微粒（EMCs）检测值高于对照组（P<0.01）。Killip分级为Ⅱ、Ⅲ、Ⅳ级分别有43、39、42例,分别占34.7%、31.5%、33.9%。分级越高,H-FABP、LVEDd、EMCs检测值越高,LVEF和 FMD检测值越低,差异均有统计学意义（均P<0.01）。血清H-FABP水平与LVEF、FMD 水平呈负相关（b=-2.764、-2.846）,与EMCs、LVEDd水平呈正相关（b=2.294、2.495）。结论 H-FABP与AMI患者心功能参数具有较好的相关性,可作为早期评价心功能的指标。

关键词: 急性心肌梗死, 心型脂肪酸结合蛋白, 心功能

Abstract: Objective To explore the relationship between serum heart-type fatty acid binding protein （H-FABP） level and cardiac function parameters in the patients with acute myocardial infarction （AMI）.Methods Patients with AMI treated in a hospital in Zigong City from May 2015 to May 2017 were selected as the case group and individuals without cardiovascular disease who underwent a physical examination at the same hospital as the control group. H-FABP and major cardiac function indexes were analyzed at different time points and compared between the two groups.Results A total of 124 patients with AMI and 124 healthy people without cardiovascular disease were enrolled in this study, including 69 males and 55 females in the case group and the same in the control group. There were no significant differences in mean age and BMI between the two groups （P>0.05 for both）. The difference of H-FABP between the two groups at different time points （2, 4, 8, 12, 24 h） was statistically significant （P<0.01）. H-FABP gradually increased before 8 h, reached a maximum at 8 h, and then gradually decreased. The H-FABP concentration in the case group was higher than that in the control group at each time point （all P<0.01）. The LVEF, LVEDd and FMD were lower in the case group than those in the control group at 8 h after onset （P<0.01）, and EMCs was higher than that in the control group （P<0.01）. There were 43, 39, and 42 cases of Killip grades at levels II, III, and IV, accounting for 34.7%, 31.5%, and 33.9%, respectively. The higher the grade, the higher the detection value of H-FABP, LVEDd and EMCs, the lower the LVEF and FMD detection values （P<0.01）. Serum H-FABP levels were negatively correlated with LVEF and FMD levels （b=-2.764, -2.846）, and positively correlated with EMCs and LVEDd levels （b=2.294, 2.495）.Conclusion H-FABP has good correlation with cardiac function parameters in patients with AMI and can be used as an index for evaluation of early cardiac function.

Key words: Acute myocardial infarction, Heart type fatty acid binding protein, Cardiac function

中图分类号:

R183.3+2

徐晓玲, 殷明刚. 心型脂肪酸结合蛋白对急性心肌梗死患者早期心功能参数评价价值[J]. 华南预防医学, 2019, 45(5): 436-439.

XU Xiao-ling, YIN Ming-gang. Value of heart-type fatty acid binding protein in evaluating early cardiac function parameters in patients with acute myocardial infarction[J]. South China Journal of Preventive Medicine, 2019, 45(5): 436-439.

参考文献 16

[1]	Agnello L, Bivona G, Novo G, et al.Heart-type fatty acid binding protein is a sensitive biomarker for early AMI detection in troponin negative patients: a pilot study[J]. Scand J Clin Lab Inv, 2017, 77(7):1-5.
[2]	朱家平, 严能兵. 心型脂肪酸结合蛋白和钙卫蛋白联合检测在ST段抬高型急性心肌梗死中的应用价值[J]. 天津中医药, 2019, 36(1):31-33.
[3]	Bivona G, Agnello L, Bellia C, et al.Diagnostic and prognostic value of H-FABP in acute coronary syndrome: still evidence to bring[J]. Clin Biochem, 2018,58: 1-4.
[4]	杜敏. 肌红蛋白联合肌钙蛋白检测在急性心肌梗死早期诊断中的应用价值分析[J]. 医学信息, 2019, 32(8):62.
[5]	Thygesen K, Alpert JS, Jaffe AS, et al.Fourth universal definition of myocardial infarction( 2018)[J]. J Am Coll Cardiol,2018,72(18):2231-2264.
[6]	刘甲兴, 杨聪德, 黄勉君, 等. 心型脂肪酸结合蛋白在急性心肌梗死6 h内的诊断价值[J]. 临床军医杂志, 2013(2):114-115.
[7]	Huang Y, Gao L, Cui H.Assembly of multifunctionalized gold nanoparticles with chemiluminescent, catalytic, and immune activity for label-free immunoassays[J]. Acs Appl Mater, 2018, 10(20): 17040-17046.
[8]	Young JM, Pickering JW, George PM, et al.Heart fatty acid binding protein and cardiac troponin: development of an optimal rule-out strategy for acute myocardial infarction[J]. Bmc Emergency Medicine, 2016, 16(1):34.
[9]	陈冬生, 栾献亭, 杨进刚,等. 中国急性心肌梗死不同Killip分级患者的临床特征、治疗和预后情况分析[J]. 中国循环杂志, 2016, 31(9):849-853.
[10]	王建飞, 张晓红, 施有为. 心型脂肪酸结合蛋白在急性心肌梗死中的超早期诊断价值[J]. 中国老年学杂志, 2018, 38(15):3607-3609.
[11]	邵春芳. 心肌型脂肪酸结合蛋白在急性心肌梗死早期诊断中的价值[J]. 中国卫生标准管理, 2018(2):120-121.
[12]	张易民,张广平.急性心肌梗死患者电生理特征Tp-ec及Tp-e/QT与心肌损伤、氧自由基生成的相关性研究[J].海南医学院学报,2017,23(19):2609-2611,2615.
[13]	徐智虎, 喻佳丽, 雷映霞. 心脏脂肪酸结合蛋白在早期急性心肌梗死诊断中的价值[J]. 心肺血管病杂志, 2018(6):506-509.
[14]	张孝春, 刘秀华, 张杰俊. 急性心肌梗死心血管内科治疗临床分析[J]. 中西医结合心血管病电子杂志, 2019, 7(1):50.
[15]	王翠华, 刘衍恭, 郑明奇, 等. 心型脂肪酸结合蛋白在心血管疾病中的作用[J]. 天津医药, 2018, 46(10):1135-1139.
[16]	Hamza M, Demerdash S, Ibrahim M.Heart-type fatty acid-binding protein as a diagnostic biochemical marker for early detection of myocardial infarction[J]. Acta Cardiol, 2016, 71(5):537-541.

心型脂肪酸结合蛋白对急性心肌梗死患者早期心功能参数评价价值

Value of heart-type fatty acid binding protein in evaluating early cardiac function parameters in patients with acute myocardial infarction

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