溃疡性结肠炎患者炎性因子水平、肠道菌群分布及发病相关因素分析

doi:10.12183/j.scjpm.2022.0178

摘要/Abstract

摘要： 目的研究溃疡性结肠炎患者的炎性因子水平、肠道菌群分布及发病相关危险因素,为溃疡性结肠炎的防治工作提供科学依据。方法以2020年6月至2021年5月在文昌市某医院就诊的溃疡性结肠炎患者作为病例组,同时选取（按年龄相差0.5岁,性别相同招揽志愿者参与本研究）同期在该医院进行健康体检者作为对照组。所有研究对象进行问卷调查、肠道菌群检测及炎症因子检测,采用描述性分析方法对2组相关指标进行比较,并对溃疡性结肠炎发病影响因素进行单、多因素分析。结果共纳入溃疡性结肠炎病例（病例组）和健康体检者（对照组）各200例,男性各99例,女性各101例,病例组平均年龄（43.17±8.72）岁,对照组平均年龄（43.54±9.11）岁,2组的年龄、性别分布差异均无统计学意义（均P>0.05）。病例组主要检出的双歧杆菌、乳杆菌数量低于对照组,拟杆菌、肠杆菌、肠球菌、梭杆菌数量高于对照组（均P<0.01）。病例组除白细胞介素（IL）-4水平低于对照组,IL-6、IL-17、IL-23以及肿瘤坏死因子-α（TNF-α）均高于对照组（均P<0.01）。饮酒（OR=3.526）、吸烟（OR=1.272）、饮食不洁（OR=4.592）、存在合并感染（OR=2.146）、情绪紧张（OR=3.919）均为溃疡性结肠炎发病的危险因素。结论溃疡性结肠炎患者肠道菌群种类、数量分布不平衡,血清炎症因子水平明显上升。良好的生活行为习惯以及积极地健康教育可降低溃疡性结肠炎的发生风险。

关键词: 溃疡性结肠炎, 炎性因子, 肠道菌群, 影响因素

Abstract: Objective To study the level of inflammatory factors, distribution of intestinal flora, and risk factors in patients with ulcerative colitis, so as to provide scientific basis for the prevention and treatment of ulcerative colitis. Methods Patients with ulcerative colitis who were treated in a hospital in Wenchang City from June 2020 to May 2021 were selected as the case group. The healthy people who underwent physical examination in the hospital （volunteers were recruited according to the age difference of 0.5 years from the case group and the same gender） were selected as the control group. All subjects were investigated by questionnaire survey, intestinal flora detection and inflammatory factor detection. Descriptive analysis method was used to compare the relevant indicators of the two groups, and the univariate and multivariate analysis methods were used to analyze the factors affecting the incidence of ulcerative colitis. Results A total of 200 cases of ulcerative colitis （case group） and 200 healthy persons （control group） were included, with 99 males and 101 females. The average age of the case group was （43.17±8.72） years, and of the control group was （43.54 ±9.11） years. There were no significant differences in the age and gender between the two groups （both P>0.05）. The numbers of Bifidobacterium and Lactobacillus mainly detected in the case group were significantly lower than that in the control group, while Bacteroides, Enterobacter, Enterococcus and Fusobacterium were significantly higher than those in the control group （all P<0.01）. Except for the level of interleukin （IL）-4 in the case group was lower than that in the control group, IL-6, IL-17, IL-23 and tumor necrosis factor （TNF）-α were all higher than those in the control group （all P<0.01）. Alcohol consumption （OR=3.526）, smoking （OR=1.272）, unclean diet （OR=4.592）, co-infection （OR=2.146） and emotional tension （OR=3.919） were all risk factors for ulcerative colitis. Conclusion The species and quantity of intestinal flora in patients with ulcerative colitis are unbalanced, and the level of serum inflammatory factors increases significantly. Good living habits and active health education can reduce the incidence of ulcerative colitis.

Key words: Ulcerative colitis, Inflammatory factor, Intestinal flora, Influencing factor

中图分类号:

R574

何碧瑜, 王佩茹, 杨维忠, 史方义. 溃疡性结肠炎患者炎性因子水平、肠道菌群分布及发病相关因素分析[J]. 华南预防医学, 2022, 48(2): 178-181.

HE Bi-yu, WANG Pei-ru, YANG Wei-zhong, SHI Fang-yi. Inflammatory factor level, intestinal flora distribution and related factors in patients with ulcerative colitis[J]. South China Journal of Preventive Medicine, 2022, 48(2): 178-181.

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