2型糖尿病患者甲状腺功能异常现状调查

doi:10.12183/j.scjpm.2022.1332

摘要/Abstract

摘要： 目的调查2型糖尿病患者甲状腺功能异常现状并分析其影响因素,为制定相关防治措施提供指导信息。方法以2021年1—12月郑州地区2所医院诊治的2型糖尿病患者为研究对象进行资料收集及甲状腺激素水平检测,采用描述性流行病学分析方法对2型糖尿病患者甲状腺功能异常现状进行分析,采用单、多因素分析方法对2型糖尿病患者甲状腺功能异常的影响因素进行分析。结果 1 348例2型糖尿病患者中甲状腺功能亢进20例、甲状腺功能减退35例、亚临床甲状腺功能亢进61例、亚临床甲状腺功能减退142例,甲状腺功能异常率为19.14%。多因素Logistic回归分析显示性别（女性OR=3.476）、年龄（OR=2.232）、BMI（≥24.0 kg/m² OR=1.988）、基础疾病（OR=1.766）、甲状腺疾病史（OR=2.992）、糖尿病病程（OR=2.646）、胰岛素治疗（OR=0.641）是2型糖尿病患者甲状腺功能异常的影响因素。结论 2型糖尿病患者甲状腺功能异常发生率较高,女性、年龄增大、超重及肥胖、有基础疾病、有甲状腺疾病史、糖尿病病程越长、未进行胰岛素治疗增加2型糖尿病患者甲状腺功能异常的发生风险,对于以上危险人群更应加强甲状腺功能监测,及早发现甲状腺功能异常并及时给予干预治疗。

关键词: 2型糖尿病, 甲状腺功能亢进, 甲状腺功能减退, 影响因素

Abstract: Objective To investigate the status of thyroid dysfunction in patients with type 2 diabetes mellitus (T2DM) and analyze its influencing factors, to guide the formulation of relevant prevention and treatment measures. Methods Data collection and thyroid hormone detection were conducted on T2DM patients diagnosed and treated in two hospitals in Zhengzhou from January to December 2021. The descriptive epidemiological analysis method was used to analyze the status of thyroid dysfunction in T2DM patients, and univariate and multivariate analysis methods were used to analyze the influencing factors of thyroid dysfunction in T2DM patients. Results Among 1 348 T2DM patients, there were 20 cases with hyperthyroidism, 35 cases with hypothyroidism, 61 cases with subclinical hyperthyroidism, and 142 cases with subclinical hypothyroidism. The rate of thyroid dysfunction was 19.14%. Multivariate Logistic regression analysis showed that gender (female, OR=3.476), age (OR=2.232), body mass index (≥24.0 kg/m², OR=1.988), underlying diseases (OR=1.766), history of thyroid diseases (OR=2.992), course of diabetes (OR=2.646), and insulin treatment (OR=0.641) were the influencing factors of thyroid dysfunction in T2DM patients. Conclusions The incidence of thyroid dysfunction is high in T2DM patients. Females, older age, overweight and obese, underlying diseases, history of thyroid diseases, a longer course of diabetes, and without insulin therapy were the risk factors of thyroid dysfunction in T2DM patients. Regular screening of thyroid function should be strengthened for the group with those risk factors, and thyroid dysfunction should be detected early and corrected in time.

Key words: Type 2 diabetes mellitus, Hyperthyroidism, Hypothyroidism, Influencing factor

中图分类号:

R581.2

付伟, 唐二云, 李丽. 2型糖尿病患者甲状腺功能异常现状调查[J]. 华南预防医学, 2022, 48(11): 1332-1335.

FU Wei, TANG Er‐yun, LI Li. Investigation on the status of thyroid dysfunction in patients with type 2 diabetes mellitus[J]. South China Journal of Preventive Medicine, 2022, 48(11): 1332-1335.

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