胎膜早破产妇生殖道病原体感染及其对母婴结局影响研究

doi:10.12183/j.scjpm.2023.0184

摘要/Abstract

摘要： 目的探讨胎膜早破产妇生殖道病原体感染对母婴结局的影响,并分析影响感染的危险因素,为降低生殖道病原体感染提供参考。方法以2018年1月1日至2021年12月31日在北京积水潭医院产检且发生胎膜早破后完成分娩的产妇为研究对象,并按是否发生生殖道病原体感染分为感染组和非感染组,收集两组产妇的相关资料及实验室检测结果,采用描述性分析方法对两组产妇的妊娠结局、新生儿结局进行比较,并采用单、多因素分析方法对产妇生殖道病原体感染的影响因素进行分析。结果本研究共纳入胎膜早破产妇1 926例,年龄20~47岁,平均年龄（32.48±5.21）岁。发生生殖道病原体感染1 153例,感染率为59.87%,其中解脲支原体感染1 121例（58.20%）,假丝酵母菌感染455例（23.62%）,细菌性阴道病351例（18.22%）,滴虫感染241例（12.51%）,沙眼衣原体感染163例（8.46%）,混合感染494例（25.65%）。多因素Logistic回归分析显示,年龄（OR=1.704）、流产史（OR=2.252）、避孕方式（OR=1.637）、生殖道感染史（OR=2.462）是胎膜早破产妇生殖道病原体感染的独立影响因素。结论胎膜早破孕产妇生殖道病原体感染检出率较高,可直接给母婴结局带来不良影响。年龄、流产史、避孕方式、生殖道感染史是孕产妇生殖道病原体感染的独立影响因素。

关键词: 胎膜早破, 生殖道病原体感染, 母婴结局, 影响因素

Abstract: Objective To investigate the effect of reproductive tract pathogen infection on maternal and infant outcomes in parturients with premature rupture of membranes, and to analyze the risk factors for infection, and thus to provide a reference for reducing reproductive tract pathogen infection. Methods Parturients who delivered after having premature rupture of membranes in Beijing Jishuitan Hospital between January 1, 2018 and December 31, 2021 were selected and divided into infected and non-infected groups based on whether they had a reproductive tract pathogen infection. Related data and laboratory test results were collected for both groups. Descriptive analysis method was used to compare the pregnancy outcomes and neonatal outcomes of the two groups, and univariate and multivariate analysis methods were used to analyze the influencing factors of reproductive tract pathogen infection. Results A total of 1 926 parturients with premature rupture of membranes were included in the study, aged 20 - 47, with an average age of （32.48±5.21） years. There were 1 153 cases of reproductive tract pathogen infection, the infection rate was 59.87%, including 1 121 cases （58.20%） of Ureaplasma urealyticum infection, 455 cases （23.62%） of Candida infection, 351 cases （18.22%） of bacterial vaginosis, 241 cases （12.51%） of Trichomonas infection, 163 cases （8.46%） of Chlamydia trachomatis, and 494 cases （25.65%） of mixed infection. Multivariate Logistic regression analysis showed that age （OR=1.704）, abortion history （OR=2.252）, contraceptive method （OR=1.637）, and reproductive tract pathogen infection history （OR=2.462） were independent influencing factors of reproductive tract pathogen infection in parturients with premature rupture of membranes. Conclusions The detection rate of reproductive tract pathogen infection is high in parturients with premature rupture of membranes, which can directly bring adverse effects on maternal and infant outcomes. Age, abortion history, contraceptive method, and reproductive tract pathogen infection history were the independent influencing factors of reproductive tract pathogen infection.

Key words: Premature rupture of membranes, Reproductive tract pathogen infection, Maternal and infant outcome, Influencing factor

中图分类号:

R195

孙文娟, 王坤, 张艳梅. 胎膜早破产妇生殖道病原体感染及其对母婴结局影响研究[J]. 华南预防医学, 2023, 49(2): 184-187.

SUN Wen-juan, WANG Kun, ZHANG Yan-mei. Reproductive tract pathogen infection in parturients with premature rupture of membranes and its effect on maternal and infant outcomes[J]. South China Journal of Preventive Medicine, 2023, 49(2): 184-187.

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