帕金森病患者非运动症状患病现状调查及对生活质量影响研究

doi:10.12183/j.scjpm.2024.0706

摘要/Abstract

摘要： 目的调查帕金森病患者非运动症状患病现状,并探讨其对生活质量影响。方法将2020年9月至2023年8月北京天坛医院收治的帕金森病患者为研究对象,获取患者年龄及性别等一般资料,采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）、帕金森病认知功能评定量表（PD-CRS）等一系列量表评估患者非运动症状,采用帕金森病生活质量量表-39（PDQ-39）评估患者生活质量,采用Spearman相关分析法分析PDQ-39量表评分与非运动症状各项量表评分的相关性,影响因素通过多重线性回归模型分析。结果本研究最终纳入1 215例帕金森病患者,各项非运动症状的发生率依次为自主神经功能障碍81.40%、疼痛65.19%、睡眠障碍53.58%、疲劳43.13%、抑郁38.85%、焦虑30.21%、认知功能障碍24.20%、冲动控制障碍22.72%及淡漠20.82%。1 215例患者PDQ-39评分平均为（43.52±5.61）分。多重线性回归分析结果显示,HAMD评分（β′=0.243）、HAMA评分（β′=0.531）、PD-CRS评分（β′=-0.287）、帕金森病预后量表-自主神经评分（β′=0.781）、匹茨堡睡眠质量指数（β′=0.478）及帕金森病疼痛量表评分（β′=0.259）均对帕金森病患者PDQ-39评分有显著影响（均P<0.01）。结论帕金森病患者自主神经功能障碍、疼痛、睡眠障碍、焦虑、抑郁等非运动症状发生率较高,且上述非运动症状越严重,患者生活质量越差,临床需寻找有效的针对性非运动症状干预措施,以综合改善患者生活质量。

关键词: 帕金森病, 非运动症状, 生活质量, 现状调查

Abstract: Objective To investigate the prevalence of non-motor symptoms in patients with Parkinson's disease and to study its impact on quality of life. Methods The Parkinson's patients admitted to Beijing Tiantan Hospital from September 2020 to August 2023 were selected for this study. The general data such as age and gender of the patients were obtained. A series of scales such as Hamilton Depression Scale （HAMD）,Hamilton Anxiety Scale （HAMA）,and Parkinson's Disease Cognitive Function Rating Scale （PD-CRS） were used to evaluate the non-motor symptoms of the patients. The Parkinson's Disease Quality of Life Scale-39 （PDQ-39） was used to evaluate the quality of life of the patients. Spearman correlation analysis was used to analyze the correlation between PDQ-39 score and non-motor symptom scale scores. The influencing factors were analyzed by multiple linear regression model. Results As a result,1 215 Parkinson's patients were ultimately included in this study. The incidence of various non-motor symptoms was as follows：autonomic dysfunction 81.40%,pain 65.19%,sleep disorders 53.58%,fatigue 43.13%,depression 38.85%,anxiety 30.21%,cognitive dysfunction 24.20%,impulse control disorder 22.72%,and apathy 20.82%. The average PDQ-39 score of 1 215 patients was （43.52 ± 5.61） points. The results of multiple linear regression analysis showed that the HAMD score （β'=0.243）,HAMA score （β'=0.531）,PD-CRS score （β'=-0.287）,Parkinson's Disease Prognostic Scale Autonomic Nerve score （β'=0.781）,Pittsburgh Sleep Quality Index （β'=0.478）,and KING′s Parkinson's Disease Pain Scale score （β'=0.259） all had a significant impact on the quality of life of Parkinson's patients （all P<0.01）. Conclusions The incidence of non-motor symptoms such as autonomic dysfunction,pain,sleep disorders,anxiety,and depression in patients with Parkinson 's disease is high,and the more serious the above non-motor symptoms,the worse the quality of life of patients. It is necessary to find effective targeted non-motor symptoms interventions to comprehensively improve the quality of life of patients.

Key words: Parkinson's disease, Non-motor symptoms, Quality of life, Status survey

中图分类号:

R473.74

杨丽娜, 柳欣, 孙金菊, 赵越颖, 邓咏梅, 宗英爽. 帕金森病患者非运动症状患病现状调查及对生活质量影响研究[J]. 华南预防医学, 2024, 50(8): 706-710.

YANG Lina, LIU Xin, SUN Jinju, ZHAO Yueying, DENG Yongmei, ZONG Yingshuang. Prevalence of non-motor symptoms in patients with Parkinson's disease and its impact on quality of life[J]. South China Journal of Preventive Medicine, 2024, 50(8): 706-710.

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