高尿酸血症的流行病学特征及其与心血管疾病的研究进展

doi:10.12183/j.scjpm.2025.0127

摘要/Abstract

摘要： 尿酸作为人体内一种重要的代谢产物,在适宜浓度下对健康起着积极作用,包括抗氧化、调节血压、增强免疫及抗衰老等功能。高尿酸血症严重威胁身体健康,其患病率的不断升高正在成为一个较为严峻的公共卫生问题。大量研究提示高尿酸血症在痛风、心血管疾病及代谢综合征等疾病的发生中发挥重要作用。本文通过系统回顾近几年国内外关于高尿酸血症的文献,旨在深入探讨高尿酸血症与人体健康之间的关系,总结高尿酸血症的流行病学特征,并探究其与心血管疾病之间的关系,从而强调控制尿酸水平对维护人体健康的重要性,并为后续研究提供新视角。

关键词: 高尿酸血症, 尿酸, 流行病学, 心血管疾病

中图分类号:

R181.3+8

李鸿钰, 田建广, 胡滨, 薛建华, 朱勤忠. 高尿酸血症的流行病学特征及其与心血管疾病的研究进展[J]. 华南预防医学, 2025, 51(2): 127-131.

参考文献

[1] Borghi C, Agabiti-Rosei E, Johnson RJ, et al.Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease[J]. Eur J Intern Med, 2020, 80: 1-11.
[2] Han Y, Cao Y, Han X, et al.Hyperuricemia and gout increased the risk of long-term mortality in patients with heart failure: Insights from the National Health and Nutrition Examination Survey[J]. J Transl Med, 2023, 21(1): 463.
[3] Shirasawa T, Ochiai H, Yoshimoto T, et al.Cross-sectional study of associations between normal body weight with central obesity and hyperuricemia in Japan[J]. BMC Endocr Disord, 2020, 20: 1-8.
[4] Li Y, Shen Z, Zhu B, et al.Demographic, regional and temporal trends of hyperuricemia epidemics in mainland China from 2000 to 2019: A systematic review and meta-analysis[J]. Glob Health Action, 2021, 14(1): 1874652.
[5] Halperin Kuhns VL, Woodward OM.Sex differences in urate handling[J]. Int J Mol Sci, 2020, 21(12): 4269.
[6] El Ridi R, Tallima H.Physiological functions and pathogenic potential of uric acid: A review[J]. J Adv Res, 2017, 8(5): 487-493.
[7] Kasahara K, Kerby RL, Zhang Q, et al.Gut bacterial metabolism contributes to host global purine homeostasis[J]. Cell Host Microbe, 2023, 31(6): 1038-1053.
[8] Du L, Zong Y, Li H, et al.Hyperuricemia and its related diseases: Mechanisms and advances in therapy[J]. Signal Transduct Target Ther, 2024, 9(1): 212.
[9] Chen XM, Yokose C, Rai SK, et al.Contemporary prevalence of gout and hyperuricemia in the United States and decadal trends: The National Health and Nutrition Examination Survey, 2007-2016[J]. Arthritis Rheumatol, 2019, 71(6): 991-999.
[10] Singh G, Lingala B, Mithal A. gout and hyperuricaemia in the USA: Prevalence and trends[J]. Rheumatology (Oxford), 2019, 58(12): 2177-2180.
[11] Maksimov SA, Shalnova SA, Deyev AD, et al.Hyperuricemia versus lifestyle in men and women of the Russian Federation population[J]. Russ Open Med J, 2020, 9(2): 214.
[12] Almuqrin A, Alshuweishi YA, Alfaifi M, et al.Prevalence and association of hyperuricemia with liver function in Saudi Arabia: A large cross-sectional study[J]. Ann Saudi Med, 2024, 44(1): 18-25.
[13] Al Shanableh Y, Hussein YY, Saidwali AH, et al.Prevalence of asymptomatic hyperuricemia and its association with prediabetes, dyslipidemia and subclinical inflammation markers among young hethy aults in Qatar[J]. BMC Endocr Disord, 2022, 22(1): 21.
[14] Hong JW, Noh JH, Kim DJ.Association between serum uric acid and spirometric pulmonary function in Korean adults: The 2016 Korea National Health and Nutrition Examination Survey[J]. PLoS One, 2020, 15(10): e0240987.
[15] Koto R, Nakajima A, Horiuchi H, et al.Real-world treatment of gout and asymptomatic hyperuricemia: A cross-sectional study of Japanese health insurance claims data[J]. Mod Rheumatol, 2021, 31(1): 261-269.
[16] Rao J, Ye P, Lu J, et al.Prevalence and related factors of hyperuricaemia in Chinese children and adolescents: A pooled analysis of 11 population-based studies[J]. Ann Med, 2022, 54(1): 1608-1615.
[17] Liu R, Han C, Wu D, et al.Prevalence of hyperuricemia and gout in mainland China from 2000 to 2014: A systematic review and meta‐analysis[J]. Biomed Res Int, 2015, 2015(1): 762820.
[18] 方勇,吴玉梅,陶琦,等. 老年体检人群高尿酸血症患病情况及影响因素分析[J]. 华南预防医学,2021,47(6):764-767.
[19] Moulin-Mares SRA, Zaniqueli D, Oliosa PR, et al.Uric acid reference values: Report on 1 750 healthy Brazilian children and adolescents[J]. Pediatr Res, 2021, 89(7): 1855-1860.
[20] Wu X, Zhou M, Bu J, et al.Prevalence and risk factors of hyperuricemia in the urban health checkup population in Xinjiang, China: A cross-sectional study[J]. Risk Manag Healthc Policy, 2023: 1531-1544.
[21] Zhang M, Zhu X, Wu J, et al.Prevalence of hyperuricemia among Chinese adults: Findings from two nationally representative cross-sectional surveys in 2015-16 and 2018-19[J]. Front Immunol, 2022, 12: 791983.
[22] Yuanyuan Q, Yunhua H, Qingyun C, et al.The prevalence of hyperuricemia and its correlates in Zhuang Nationality, Nanning, Guangxi Province[J]. J Clin Lab Anal, 2022, 36(11): e24711.
[23] Gao Y, Cui LF, Sun YY, et al.Adherence to the dietary approaches to stop hypertension diet and hyperuricemia: A cross-sectional study[J]. Arthritis Care Res (Hoboken), 2021, 73(4): 603-611.
[24] Zhu Q, Yu L, Li Y, et al.Association between dietary approaches to stop hypertension(DASH) diet and hyperuricemia among Chinese adults: Findings from a nationwide representative study[J]. Nutr J,2023, 22(1): 21.
[25] 黄叶飞,杨克虎,陈澍洪,等. 高尿酸血症/痛风患者实践指南[J].中华内科杂志,2020,59(7):519-527.
[26] 中华医学会内分泌学分会. 中国高尿酸血症与痛风诊疗指南(2019)[J].中华内分泌代谢杂志,2020,36(1):1-13.
[27] World Health Organization. World Health Statistics2021: Monitoring health for the SDGs, sustainable development goals[EB/OL].(2021-05-20)[2024-04-20]. https://www.who.int/publications/i/item/9789240027053.
[28] Chen F, Yuan L, Xu T, et al.Association of hyperuricemia with 10-year atherosclerotic cardiovascular disease risk among Chinese adults and elders[J]. Int J Environ Res Public Health, 2022, 19(11): 6713.
[29] Tian X, Chen S, Wang P, et al.Temporal relationship between hyperuricemia and hypertension and its impact on future risk of cardiovascular disease[J]. Eur J Intern Med, 2023, 111: 82-89.
[30] 李琳,谷永胜,秦璐,等. 正常血尿酸人群中血尿酸水平对颈动脉粥样硬化进展的影响:一项体检人群的10年队列研究[J]. 中国全科医学,2022,25(23):2836-2843.
[31] Huang Y, Chen S, Yang X, et al.Impact of serum uric acid on subclinical myocardial injury in general population[J]. Nutr Metab Cardiovasc Dis, 2022, 32(3): 641-647.
[32] He C, Lin P, Liu W, et al.Prognostic value of hyperuricemia in patients with acute coronary syndrome: A meta‐analysis[J]. Eur J Clin Invest, 2019, 49(4): e13074.
[33] Tatsumi Y, Asayama K, Morimoto A, et al.Hyperuricemia predicts the risk for developing hypertension independent of alcohol drinking status in men and women: The Saku study[J]. Hypertens Res, 2020, 43(5): 442-449.
[34] Cao Z, Cheng Y, Li S, et al.Mediation of the effect of serum uric acid on the risk of developing hypertension: A population-based cohort study[J]. J Transl Med, 2019, 17(1): 202.
[35] Battelli M G, Bortolotti M, Polito L, et al.The role of xanthine oxidoreductase and uric acid in metabolic syndrome[J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864(8): 2557-2565.
[36] Ghasemi A.Uric acid-induced pancreatic β-cell dysfunction[J]. BMC Endocr Disord, 2021, 21(1): 24.
[37] Bombelli M, Quarti-Trevano F, Tadic M, et al.Uric acid and risk of new-onset metabolic syndrome, impaired fasting glucose and diabetes mellitus in a general Italian population: Data from the Pressioni Arteriose Monitorate E Loro Associazioni study[J]. J Hypertens, 2018, 36(7): 1492-1498.
[38] Wang C, Wang J, Wan R, et al.Relationship between baseline and changed serum uric acid and the incidence of type 2 diabetes mellitus: A national cohort study[J]. Front Public Health, 2023, 11: 1170792.
[39] Song J, Jin C, Shan Z, et al.Prevalence and risk factors of hyperuricemia and gout: A cross-sectional survey from 31 provinces in mainland China[J]. J Transl Int Med, 2022, 10(2): 134-145.
[40] 赵晶晶,孙纪新,单广良,等. 河北省不同性别成人血尿酸水平与代谢综合征的相关性分析[J]. 中国慢性病预防与控制,2022,30(2):112-116.
[41] Gou R, Dou D, Tian M, et al.Association between triglyceride glucose index and hyperuricemia: A new evidence from China and the United States[J]. Front Endocrinol (Lausanne), 2024, 15: 1403858.