血清空腹血糖与高密度脂蛋白胆固醇比值与代谢相关脂肪性肝病相关性分析

doi:10.12183/j.scjpm.2025.1332

华南预防医学 ›› 2025, Vol. 51 ›› Issue (12): 1332-1336.doi: 10.12183/j.scjpm.2025.1332

血清空腹血糖与高密度脂蛋白胆固醇比值与代谢相关脂肪性肝病相关性分析

游梦婷, 张泽丹, 苏继源, 包维为, 谭平

中国人民解放军联勤保障部队第九〇〇医院,福建福州 350025

收稿日期:2025-03-06 出版日期:2025-12-20 发布日期:2026-01-07
通讯作者: 包维为,E-mail：bwwei937066@163.com
作者简介:游梦婷（1995—）,女,硕士研究生,医师,主要从事流行病学及健康管理工作
基金资助:
福建省自然科学基金（2024J011150）

Correlation between the ratio of fasting blood glucose to high density lipoprotein cholesterol and metabolic associated fatty liver disease

YOU Mengting, ZHANG Zedan, SU Jiyuan, BAO Weiwei, TAN Ping

900th Hospital of PLA Joint Logistic Support Force, Fuzhou, Fujian 350025, China

Received:2025-03-06 Online:2025-12-20 Published:2026-01-07

摘要/Abstract

摘要： 目的探讨血清空腹血糖与高密度脂蛋白胆固醇比值（GHR）与代谢相关脂肪性肝病（MAFLD）的相关性。方法回顾性纳入2021年1月至2023年12月于中国人民解放军联勤保障部队第九〇〇医院健康体检中心的体检者为研究对象,采用多因素logistic回归分析GHR与MAFLD的关联性,利用限制性立方样条（RCS）探索非线性关系,并通过受试者工作特征曲线（ROC）评估GHR的预测效能。结果共纳入17 472名体检者,其中MAFLD 6 403例,非MAFLD 11 069人。在逐步调整了各种混杂因素后,GHR与MAFLD仍呈显著正相关（P<0.001）;每增加一个单位的GHR,MAFLD风险增加14.9%。与最低GHR四分位数Q1组相比,Q2、Q3和Q4组患MAFLD的风险分别是Q1组的1.507、2.045和2.721倍;MAFLD患病风险随GHR四分位数增加而增加（P_trend<0.001）。RCS分析提示GHR与MAFLD呈非线性关联（P<0.001）,其特征呈倒L型曲线,拐点为5.739。ROC曲线分析显示,GHR预测MAFLD显著优于单独使用HDL-C或FBG,其曲线下面积（AUC）为0.769。结论 GHR是MAFLD的独立影响因素,可作为预测MAFLD的潜在生物标志物。

关键词: 代谢相关脂肪性肝病, 空腹血糖, 高密度脂蛋白胆固醇

Abstract: Objective To investigate the correlation between the ratio of fasting blood glucose to high density lipoprotein cholesterol (GHR) and metabolically associated fatty liver disease (MAFLD). Methods A retrospective study was conducted on individuals who underwent physical examinations at our hospital from January 2021 to December 2023. Multivariate logistic regression was used to analyze the association between GHR and MAFLD. The restricted cubic spline (RCS) was employed to explore the non-linear relationship, and the predictive efficacy of GHR was evaluated through the receiver operating characteristic curve (ROC). Results A total of 17 472 subjects were included, among which 6 403 had MAFLD and 11 069 did not. After stepwise adjustment for various confounding factors, GHR was still significantly positively correlated with MAFLD (P<0.001); for each unit increase in GHR, the risk of MAFLD increased by 14.9%. Compared with the lowest GHR quartile Q1 group, the risks of MAFLD in Q2, Q3, and Q4 groups were 1.507, 2.045, and 2.721 times that of the Q1 group, respectively; the risk of MAFLD increased with the increase in GHR quartiles (P_trend<0.001). RCS analysis indicated a nonlinear association between GHR and MAFLD (P<0.001), with an inverted L-shaped curve and a turning point at 5.739. ROC curve analysis showed that GHR was significantly better than HDL-C or FBG alone in predicting MAFLD, with an area under the curve (AUC) of 0.769. Conclusion GHR is an independent risk factor for MAFLD and may serve as a promising biomarker for predicting MAFLD.

Key words: Metabolic associated fatty liver disease, Fasting blood glucose, High density lipoprotein cholesterol

中图分类号:

R589

游梦婷, 张泽丹, 苏继源, 包维为, 谭平. 血清空腹血糖与高密度脂蛋白胆固醇比值与代谢相关脂肪性肝病相关性分析[J]. 华南预防医学, 2025, 51(12): 1332-1336.

YOU Mengting, ZHANG Zedan, SU Jiyuan, BAO Weiwei, TAN Ping. Correlation between the ratio of fasting blood glucose to high density lipoprotein cholesterol and metabolic associated fatty liver disease[J]. South China Journal of Preventive Medicine, 2025, 51(12): 1332-1336.

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血清空腹血糖与高密度脂蛋白胆固醇比值与代谢相关脂肪性肝病相关性分析

Correlation between the ratio of fasting blood glucose to high density lipoprotein cholesterol and metabolic associated fatty liver disease

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