Abstract: Objective To analyze the epidemiological characteristics of hand, foot, and mouth disease (HFMD) and its correlation with meteorological factors in Qingcheng District, Qingyuan, so as to provide scientific evidences for control and prevention measures. Methods Epidemic surveillance data from 2009 to 2013 in Qingcheng District were obtained from China Information System for Disease Prevention and Control, and corresponding meteorological data, from Qingyuan Climate Monitoring System. Descriptive epidemiological method was conducted to analyze epidemiological characteristics of HFMD and multiple regressions were adopted to test the correlation between the number of HFMD cases and meteorological factors. Results A total of 17 768 HFMD cases were reported from 2009 to 2013, with an average annual incidence of 517.55/100 thousand. The incidence was increased year by year from 2009 to 2011, while decreased dramatically from 2012 to 2013. Cases were reported in every street (town) around the district. The annual incidence was the highest in Dongcheng street, the combination zone between urban and rural area (724.840/100 thousand).Most cases were mainly distributed from April to July (56.60%,10 056/17 768), 95.04% (16 886/17 768) of them was children aged 5 years or younger, and 83.29% (14 800/17 768) was scattered children. There were 11 531 male cases and 6 237 female cases, and their average annual incidence rates were 651.25/100 thousand and 375.50/100 thousand, respectively. The ratio of male to female incidences was 1.73∶1. EV 71 was the predominant strain of HFMD in this district (62.50%, 75/120). The increase in HFMD cases showed a positive correlation with the daily average temperature, precipitation, and daily average wind speed, respectively（β=0.264, 0.079, and 0.064, P<0.05 or P<0.01）, but a negative one with the daily average air pressure (β=-0.166, P<0.01). Conclusion The occurrence of HFMD varied in area, season, age, gender, and occupation, and indicated a close correlation with the meteorological factors. Main actions should be taken to the focus groups and key locations to prevent and control HFMD before the epidemic season.