Abstract: Objective To establish a method for determination of Be, Cr, Cu, As, Cd, Sb, Ba, Hg, Tl, and Pb in hemodialysis water by inductively coupled plasma mass spectrometry (ICP-MS) with octopole reaction system (ORS) for practical requirement. Methods Contents of Be, Cr, Cu, As, Cd, Sb, Ba, Hg, Tl, and Pb in samples of hemodialysis water were determined by ICP-MS, using 45Sc, 89Y, 103Rh, and 175Lu as the internal standard elements. Results Linear relationships of the ten elements were optimal in the range of 0.0-50.0 μg/L. The correlation coefficients were 0.999 5-1.000 0, the limits of detection were between 0.002-0.069 μg/L, the determination limits were 0.007-0.230 μg/L, the relative standard deviation were 0.57%-10.76%, and the spike recoveries were 85.0%-106.9%. Conclusion The method was quick and accurate to determine Be, Cr, Cu, As, Cd, Sb, Ba, Hg, Tl, and Pb in hemodialysis water by ICP-MS with ORS.