Abstract: Objective To explore the epidemic situation of HIV/AIDS in Meizhou City and provide the scientific basis for HIV/AIDS control and prevention．Methods Data of the HIV/AIDS epidemic, sentinel surveillance, and epidemiological survey in Meizhou City from 1992 to 2013 were obtained from the National HIV/AIDS Comprehensive Control and Prevention Information System and analyzed by descriptive epidemiology method．Results The first case of HIV infection was reported in 1992．A cumulative total of 390 HIV/AIDS cases in Meizhou City were reported as of December 31, 2013．Of them, 214 cases were HIV infection, 176 cases were AIDS, and 161 cases were dead; 274 were males and 116, females. The male to female ratio was 2.36∶1．The age distribution ranged mainly from 20 to 49 years, accounting for 68.72% (268/390) of the total cases. The occupation was mainly the peasant (32.31%, 126/390）, followed by the housework and unemployed (14.10%, 55/390）. The heterosexual contact was the main route of HIV transmission (75.64%, 295/390）. Conclusion HIV/AIDS has entered a period of rapid growth in Meizhou City. The epidemic continues to spread from high-risk groups to the general population. The most important strategy of HIV/AIDS control and prevention should focus on the general population and high-risk groups.