Abstract: ObjectiveTo understand the epidemiological features of human infection with avian influenza virus in Guangdong Province.MethodsDemographic and epidemiologic data on human cases reported during 1998-2014 were collected and analyzed.Epidemiological characteristics and exposure factors of the cases were analyzed by using the method of descriptive epidemiology.ResultsA total of 130 cases infected with avian influenza A viruses were reported from 1998 to 2014, including 4 cases of H5N1, 1 case of H5N6, 1 case of H5 subtype , 113 cases of H7N9,11 cases of H9N2, 43 deaths, with a mortality rate of 33.08%; 81.54% (106/130) of cases occurred from January to March and in December, and 67.69% (88/130) occurred in the Pearl River Delta area.Among all the cases, 81 were male and 49 were female, with a male to female ratio of 1.65∶1; 48.44%（62/128）of cases aged 55 years and over, 92.31% (120/130) had clear exposure to live poultry; 8.33% (10/120) engaged in poultry related occupations, 41.67% (50/120) contacted with poultry, and 50.00% (60/120) had exposure to wet markets with live poultry.ConclusionThe epidemic peaks of human infections with avian influenza virus in Guangdong appeared in winter and spring, with certain regional clusters．The main source of infection was exposure to the live poultry and wet markets with live poultry.