Abstract: Objective To analyze the incidence trend of hepatitis A in China from 2005 to 2021,and provide the scientific reference for the prevention and treatment of hepatitis A. Methods Disease data and population data were obtained from the Public Health Science Data Center of the Chinese Center for Disease Control and Prevention and the work dynamics of the Bureau of Disease Control and Prevention of the National Health Commission,as well as the population data of the National Bureau of Statistics. Joinpoint regression model was used to analyze the reported incidence trend of hepatitis A in China. Results A total of 582 531 cases of hepatitis A were reported in China from 2005 to 2021,with an average annual reported incidence of 2.5343/100 000 and an average annual percent change （AAPC） of -10.00% （P<0.001）,showing a downward trend. From 2005 to 2018,the reported incidence of hepatitis A showed a decreasing trend in 26 provincial administrative regions （P<0.05 or P<0.01）,and a stable trend in 5 provincial administrative regions （all P>0.05）. There was no statistical significance in the 1-year-old group and the ≥85 year-old group （both P>0.05）,and the other age groups showed a downward trend （all P<0.01）. Conclusion The overall reported incidence of hepatitis A in China from 2005 to 2021 is in a downward trend,but it is still necessary to implement health education and strengthen the disease prevention awareness and self-protection ability of the population.

Key words: Hepatitis A, Incidence trend, Joinpoint regression model