Abstract: ObjectiveTo investigate the prevalence of hyperuricemia and its correlation with cardiovascular risk factors in physical examination population in Zhangjiakou City, Hebei Province, so as to provide scientific evidence for prevention of hyperuricemia.MethodsIndividuals receiving physical examination were selected to participate in the survey from May 2016 to May 2017 in a hospital of Zhangjiakou. Their blood uric acid (BUA), blood pressure (BP), body mass index (BMI), fasting blood glucose (FBG), triglyceride (TG), and total cholesterol (TC) were tested. Based on the BUA level of the four percentile interval, the different distributions of these indexes between gender groups were analyzed.According to the standard of each index, the prevalence of hyperuricemia and its relationship with each index were compared. Spearman rank correlation analysis was used to analyze the correlation of BUA level with various indexes. Factors associated with hyperuricemia were identified with multivariate logistic regression.ResultsThe prevalence rate of hyperuricemia was 23.50% (4 060/17 273); the prevalence in males (31.22%) was higher than that in females (12.04%) (P<0.01). The distributions of age, BMI, systolic BP, diastolic BP, FBG, TG, and TC in different BUA groups were statistically different in male and female groups (all P<0.01). The prevalence of hyperuricemia in males decreased with age (P<0.01), while increased in females with age (P<0.01). The prevalence of hyperuricemia in men and women increased as the BMI index increased (both P<0.01). The prevalence rates of hyperuricemia in hypertension group and hyperlipidemia group were higher than those in normal group (all P<0.01). The prevalence of hyperuricemia in female hyperglycemia group was higher than that in normal blood glucose group (P<0.01), while the prevalence in male group was lower than that in normal blood glucose group (P<0.01). The Spearman rank correlation analysis showed that levels of BUA were positively correlated with BMI, systolic BP and diastolic BP, FBG, TC and TC in the total population and the female groups (both P<0.01), while in males the level of BUA was negatively correlated with FBG (r=-0.064, P<0.01) and were positively correlated with other indicators (all P<0.01). Logistic regression analysis showed that obesity or overweight (OR=2.273), high TG (OR=2.227) and high TC (OR=1.121) were risk factors for hyperuricemia,while the female (OR=0.398) and high FBG (OR=0.686) were protective factors. ConclusionThe prevalence of hyperuricemia was high in Zhangjiakou area，and had a causal or synergistic relationship with cardiovascular disease risk factors of overweight/obesity and hyperlipidemia.