Abstract: Objective To analyze the health-adjusted life expectancy （HALE） and its variation in Guangdong Province and its 21 cities between 2005 and 2015. Methods The death data based on county level in Guangdong between 2005 and 2015 were collected and analyzed. The proportional relationship between years of life lost （YLL） and years lived with disability （YLD） in Guangdong in global burden of disease （GBD） 2015 and the mixed effect model were used to estimate the YLD rate of diseases. The HALE was calculated by Sullivan method based on the abridged multiple-decrement life tables. Results In 2015, the life expectancy （LE） and HALE of residents in Guangdong were 77.88 years and 68.88 years respectively, higher than that in 2005; the HALE loss due to disability （LHE） of the 0-year-old group in Guangdong was 9.00 years, higher than 7.84 years in 2005. Except for very few age groups, the LE, HALE, LHE and LHE/LE of women in Guangdong were higher than those of men. Variations of HALE could be observed among cities in Guangdong. Conclusions The HALE, LE and LHE in Guangdong increased between 2005 and 2015. The regional development of HALE and LE in cities across the province is unbalanced, which shows that the developed cities are higher than the underdeveloped cities.

Key words: Health-adjusted life expectancy, Life expectancy, Burden of disease