Abstract: Objective To understand HIV positive rate and its correlation among voluntary counseling and testing (VCT) in Zhongshan City, Guangdong Province. Methods The VCT data during 2010 to 2012 in Zhongshan City were downloaded from China information system for disease control and prevention. HIV and syphilis serological detection were performed for all VCT participants. The HIV positive rates were analyzed using the single factor and multifactor unconditioned logistic regression. Results Three VCT sites received 3613 clients during 2010 to 2012. Of the 3601 (99.7%) clients having HIV test, 212 (5.9%) were positive. The HIV positive rates were 5.8% (173/2972) for male and 6.2% (39/629) for female. Of the 2759 clients having syphilis test, 121 (4.4 %) were positive. The syphilis seropositive rate was 4.9% (117/2 389) for male and 1.1% (4/370) for female. The HIV positive rate for syphilis seropositive clients was 25.6% (31/121). The HIV positive rates were 66.7% (8/12) for those suspected positive in history test, 17.6% (3/17) for those with blood transfusion or sale history, 13.1% (29/221) for those having a positive regular sexual partner, 12.7% (8/63) for those injecting drug use, 10.4% (114/1 096) for those men who had sex with men (MSM), 6.3% (3/48) for those with sex transmitted disease history, 5.9% (4/68) for those having a regular sexual partner with high risk behaviors, 3.0% (1/33) for those whose mothers were HIV positive, 2.5% (22/896) for those with unmarried heterosexual behaviors, and 2.4% (20/825) for those with commercial heterosexual behaviors. Clients with occupation exposure, positive family members except for the mother, unsafe behaviors such as exelcymosis and needling, health examination, or fear of AIDS were all screened to be HIV negative. The multifactor logistic regression model showed that, the lower level of education (AOR=1.39), had a higher risk to be HIV positive; clients with syphilis seropositive tests were 4.14 times the risk to be HIV positive compared to those with syphilis seronegative tests; MSM were 4.78 times the risk to be HIV positive compared to those with unmarried heterosexual behaviors, and those with a positive regular sexual partner were 4.71 times the risk to be HIV positive compared to those with unmarried heterosexual behaviors (all P<0.01). Conclusion Clients of the low level of education, the syphilis seropositive, MSM, and those with a positive regular sexual partner have a relative high HIV infection rate. It is necessary to take more comprehensive and effective prevention measures and intervention.