Abstract: Objective To explore the status of enteral nutrition （EN） tolerance and its influencing factors in patients undergoing radical gastrectomy. Methods From January 2021 to December 2023，1 347 inpatients who underwent radical gastrectomy and received EN at Nantong Tumor Hospital were selected for this study. They were divided into the EN tolerance group （499 cases） and the EN intolerance group （848 cases） based on whether gastrointestinal discomfort occurred during EN. The current status of EN tolerance in patients after radical gastrectomy was investigated，and relevant patient data were collected to analyze the main factors affecting their EN tolerance. Results The incidence of EN intolerance among patients who underwent radical gastrectomy was 62.95% （848/1 347），while the EN tolerance rate was 37.05% （499/1 347）. Among the patients with EN intolerance，the incidence of diarrhea was 41.98% （356/848），abdominal distension was 36.79% （312/848），gastric retention was 18.04% （153/848），and vomiting/reflux was 3.18% （27/848）. Multivariate Logistic regression analysis demonstrated that age （OR=2.519），EN catheterization method （nasal jejunal tube OR=0.643，fistula OR=2.996），the time of first postoperative mobilization （>4 h OR=0.567），the type of nutritional preparation （OR=3.705），the use of sedative/analgesic drugs （OR=2.474），and the initial EN infusion method （OR=3.434） were independent influencing factors on EN tolerance in patients after radical gastrectomy. Conclusions The incidence of EN intolerance after radical gastrectomy is relatively high，with factors such as age，EN catheterization method，and the time of first postoperative mobilization exerting an influence. Clinically，appropriate EN feeding strategies should be adopted based on the patient's actual condition to minimize the occurrence of feeding intolerance.

Key words: Radical gastrectomy, Enteral nutrition, Influencing factor, Feeding intolerance