Abstract: Objective To analyze the epidemiological characteristics of the incidence and death of digestive system malignancies in Weihai residents,and provide a reference for evaluating and improving the interventional measurements. Methods Based on the surveillance data of digestive system malignancy of residents in Weihai from 2015 to 2022 and the population data of the same period,the annual percentage change （APC） of the morbidity and mortality of esophageal cancer,gastric cancer,colorectal cancer,liver cancer,gallbladder cancer,and pancreatic cancer were calculated,and their time variation trends were analyzed. Results From 2015 to 2022,the standardized morbidity of digestive system malignancies in Weihai ranged from 58.82 to 72.88 per 100 000 population,while the standardized mortality ranged from 38.72 to 47.40 per 100 000 population. Colorectal cancer,gastric cancer,and liver cancer were responsible for the majority of the morbidity and mortality among the digestive system malignancies. For both males and females,the morbidity of colorectal cancer showed a statistically significant increasing trend （P<0.05 or P<0.01）;in contrast,the morbidity of liver cancer exhibited a statistically significant decreasing trend （P<0.05 or P<0.01）. The mortality of colorectal cancer also displayed a statistically significant upward trend for both genders （P<0.05 or P<0.01）,whereas the mortality for gastric cancer and liver cancer demonstrated a statistically significant downward trend （all P<0.01）. The morbidity and mortality of digestive system malignancies were higher in males than in females,with differences in the peak age of onset for the major types of malignancies. Conclusions The morbidity and mortality of digestive system malignancies in Weihai have remained stable from 2015 to 2022,with gastric cancer,liver cancer,and colorectal cancer accounting for a significant proportion of both. It is important to note that the trends in morbidity and mortality vary among different types of cancers,thus requiring specific measures to be implemented for precise prevention and control strategies.

Key words: Digestive system malignancy, Epidemiology, Annual percentage change, Disease surveillance