Abstract: Objective To investigate direct medical expenses and their constitutions of tuberculosis (TB) patients in Baoan District, Shenzhen City, to provide a basis for establishing and perfecting tuberculosis control strategy and optimizing the allocation of medical resources.Methods All TB patients who were registered and completed the treatment in the Chronic Diseases Prevention and Treatment Hospital of Baoan District from 2008 to 2012 were investigated.The data such as demographic characteristics, therapy and classification, diagnosis, and therapy management were collected from TB management information system and expense information system.A multiple linear regression model was employed to analyze influential factors of TB treatment expenses.