Abstract: Objective To analyze epidemic characteristics of influenza in Mianyang from 2010 to 2013 so as to provide basis for making prevention and control strategy. Methods Influenza-like illness (ILI) surveillance data, pathogen testing results and influenza virus outbreak information were collected in Mianyang from 2010 to 2013 for analysis. Results A total of 50 277 ILI cases were reported by three surveillance hospitals in 2010-2013, accounting for 2.47% of the total outpatients. The percentages of ILI were 2.71%, 1.83%, 2.72%, and 2.55% from 2010-2013, respectively. Most cases were children aged 0-4 years, accounting for 47.59% of the total cases. A total of 3 213 specimens of ILI cases were detected by real time RT-PCR and 314 specimens were positive nucleic acid of influenza virus, with a positive rate of 9.77%. Of influenza virus positive stains, 110 were A/H1N1, 16 were A (unclassified), 109 were A/H3, and 79 were B. Conclusion Influenza activity was relatively stable in Mianyang from 2010 to 2013, presenting many types and subtypes of influenza virus.