关键词: 肺结核, 结核分枝杆菌, 耐药, 影响因素

Abstract: Objective To analyze the drug resistance and its risk factors of pulmonary tuberculosis patients, so as to provide basis for the prevention and control of drug resistant tuberculosis. Methods Data of 1 201 hospitalized tuberculosis patients in designated hospitals and drug sensitivity of M.tuberculosis were collected. Descriptive epidemiological analysis was used to analyze the data, and univariate and multivariate Logistic regressions were used to analyze the factors influencing drug resistance of M.tuberculosis. ResultsThe average age of 1 201 patients with pulmonary tuberculosis was （40.2 ±18.7） years （range, 6-88 years）. Among them, 829 （69.03%） were male and 372 （30.97%） were female; 1 065 （88.68%） were newly treated and 136 （11.32%） were retreated. The total drug resistance rate of newly treated patients （27.89%） was lower than that of retreated patients （62.50%） （P < 0.01）. The drug resistance rate of any drug, multi drug resistance rate and extensive drug resistance rate were significantly different between newly treated and retreated patients （P < 0.05 or P < 0.01）. The risk factors of drug resistance in newly treated patients were anti tuberculosis treatment history （OR=1.777） and diabetes mellitus （OR=1.568）, and in retreated patients were treatment ≥ 2 times （OR=3.428）, living in villages and towns （OR=3.053） and age of 41-60 years （OR=2.866）. ConclusionThe drug resistance rate of pulmonary tuberculosis patients in this area is higher, and the drug resistance rate of retreated patients is higher than that of newly treated patients. The influencing factors of drug resistance of newly treated patients and retreated patients are different. Corresponding treatment and control measures should be taken according to different types of patients to avoid drug resistance.

Key words: Pulmonary tuberculosis, Mycobacterium tuberculosis, Drug resistance, Influencing factor