新型冠状病毒感染次数对患者健康状况影响

doi:10.12183/j.scjpm.2025.0402

华南预防医学 ›› 2025, Vol. 51 ›› Issue (4): 402-407.doi: 10.12183/j.scjpm.2025.0402

新型冠状病毒感染次数对患者健康状况影响

王娟¹, 梁嘉敏², Lukatie², 曾玲珑², 谢东明², 王志伟¹, 彭志丽¹, 吕嘉春²

1.广州市疾病预防控制中心,广东广州 510440;
2.广州医科大学公共卫生学院

收稿日期:2024-09-29 出版日期:2025-04-20 发布日期:2025-05-26
通讯作者: 吕嘉春,E-mail：jiachunlu@163.com;彭志丽,E-mail：871270171@qq.com
作者简介:王娟（1973—）,女,大学本科,助理研究员,研究方向：公共卫生管理
基金资助:
广州市科技计划项目（2023A03J0463,20220602JBGS04）

Impact of the Number of COVID-19 infections on patients' health status

WANG Juan¹, LIANG Jiamin², Lukatie², ZENG Linglong², XIE Dongming², WANG Zhiwei¹, PENG Zhili¹, LYU Jiachun²

1. Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong 510440, China;
2. School of Public Health, Guangzhou Medical University

Received:2024-09-29 Online:2025-04-20 Published:2025-05-26

摘要/Abstract

摘要： 目的探讨新型冠状病毒感染（简称新冠感染）次数对患者症状严重程度和生活质量的影响。方法于2023年11—12月通过广州市12320卫生热线平台随机选取新冠感染患者,通过慢性阻塞性肺疾病评估测试（COPD assessment test,CAT）评估患者的生活质量和病情严重程度。分析新冠患者感染次数及症状严重程度,采用logistic回归分析新冠感染次数与CAT评分的关系。结果 2 809例新冠患者平均年龄（37.10±13.70）岁,男女比例为1.15∶1。感染1次1 184例（42.15%）,感染2次1 248例（44.43%）,感染≥3次377例（13.42%）。症状较轻（CAT评分≤20分）2 505例（89.18%）,症状严重（CAT评分>20分）304例（10.82%）。多因素logistic回归校正相关因素后结果显示,新冠感染2次（OR=1.41,95% CI：1.07~1.86）、新冠感染3次（OR=2.39,95% CI：1.69~3.36）是症状严重的危险因素。结论重复感染新冠病毒可能对新冠患者症状严重程度及生活质量造成严重影响,预防新冠病毒再次感染对居民后续健康显得尤为重要。

关键词: 新冠感染次数, 症状严重程度, 生活质量, 慢性阻塞性肺疾病评估测试, 重复感染

Abstract: Objective To explore the impact of the number of COVID-19 infections on the severity of symptoms and quality of life. Methods From November to December 2023, patients infected with the novel coronavirus (COVID-19) were randomly selected through the Guangzhou 12320 Health Hotline platform. The quality of life and severity of the condition were assessed using the Chronic Obstructive Pulmonary Disease Assessment Test (CAT) score. The number of COVID-19 infections and symptom severity were analyzed, and logistic regression was used to examine the relationship between the number of infections and CAT scores. Results Among the 2 809 COVID-19 patients, the average age was 37.10 ± 13.70 years, with a male-to-female ratio of 1.15:1. There were 1 184 cases (42.15%) with one infection, 1 248 cases (44.43%) with two infections, and 377 cases (13.42%) with three or more infections. Mild symptoms (CAT score≤20) were observed in 2 505 cases (89.18%), while severe symptoms (CAT score>20) were observed in 304 cases (10.82%). After adjusting for relevant factors using multivariate logistic regression, the results showed that two COVID-19 infections (OR=1.41, 95% CI: 1.07-1.86) and three or more infections (OR=2.39, 95% CI: 1.69-3.36) were risk factors for severe symptoms. Conclusions Repeated COVID-19 infections may significantly impact the severity of symptoms and quality of life in patients. Preventing reinfection with the COVID-19 is particularly important for the long-term health of residents.

Key words: Number of COVID-19 infections, Symptom severity, Quality of life, Chronic obstructive pulmonary disease assessment test (CAT Score), Reinfection

中图分类号:

R183.3

王娟, 梁嘉敏, Lukatie, 曾玲珑, 谢东明, 王志伟, 彭志丽, 吕嘉春. 新型冠状病毒感染次数对患者健康状况影响[J]. 华南预防医学, 2025, 51(4): 402-407.

WANG Juan, LIANG Jiamin, Lukatie, ZENG Linglong, XIE Dongming, WANG Zhiwei, PENG Zhili, LYU Jiachun. Impact of the Number of COVID-19 infections on patients' health status[J]. South China Journal of Preventive Medicine, 2025, 51(4): 402-407.

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新型冠状病毒感染次数对患者健康状况影响

Impact of the Number of COVID-19 infections on patients' health status

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