华南预防医学 ›› 2025, Vol. 51 ›› Issue (4): 408-412.doi: 10.12183/j.scjpm.2025.0408

• 论著 • 上一篇    下一篇

化橘红胎食用安全性评估

李欣1, 王萍2, 彭宝莹1, 王凤岩1, 彭接文2, 龙朝阳1, 梁远进3, 黄志彪1   

  1. 1.广东省疾病预防控制中心,广东 广州 511430;
    2.广东省公共卫生研究院;
    3.茂名市中医药事业发展中心
  • 收稿日期:2024-11-11 出版日期:2025-04-20 发布日期:2025-05-26
  • 通讯作者: 梁远进,E-mail:653824982@qq.com;黄志彪,E-mail:gdsjkzx_hzb@gd.gov.cn
  • 作者简介:李欣(1973—),女,博士研究生,主任医师,主要研究方向为食品安全
  • 基金资助:
    广东省医学科学技术研究基金项目(C2023005); 梅州市2023年农业领域应用基础研究项目(2023C0301001)

Food safety assessment of Citrus grandis fructus immaturus

LI Xin1, WANG Ping2, PENG Baoying1, WANG Fengyan1, PENG Jiewen2, LONG Chaoyang1, LIANG Yuanjin3, HUANG Zhibiao1   

  1. 1. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, Guangdong 510430, China;
    2. Guangdong Provincial Institute of Public Health;
    3. Maoming Center of Traditional Chinese Medicine Development
  • Received:2024-11-11 Online:2025-04-20 Published:2025-05-26

摘要: 目的 对化橘红胎的食用安全性进行评估。方法 通过对化橘红胎活性成分、重金属、农药残留等污染物和微生物指标检测分析、化橘红胎食用历史、人群食用安全性调查,结合其毒理学安全性评价结果,综合分析食用化橘红胎的健康风险。结果 化橘红胎富含柚皮苷、野漆树苷等黄酮类物质。受检样品中重金属、农药残留等污染物含量及微生物指标均符合相关限量要求。毒理学安全性试验中,化橘红胎未表现出急性毒性、遗传毒性和亚急性毒性,未观察到毒作用剂量(no observed adverse effect level,NOAEL)为10.0 g/kg BW,根据广东19个地市居民化橘红消费量情况选择茂名化州市为典型消费地区进行化橘红胎的食用情况调查,化橘红胎以泡水、煮水、煲汤等非直接食用方式为主,典型消费地区人群每日摄入量均值为1.19 g/d。未见有食用不良反应的报告。结论 除孕妇、乳母、18岁以下人群,化橘红胎成人每日摄入量不超过6.0 g对健康的潜在风险较低。

关键词: 化橘红胎, 食用, 安全性评价

Abstract: Objective To assess the food safety of consuming Citrus grandis fructus immaturus. Methods The health risks associated with consuming citrus Citrus grandis immaturus were comprehensively analyzed by detecting and analyzing its active components, contaminants (such as heavy metals and pesticide residues), and microbial indicators, combined with its consumption history, population safety surveys, and toxicological safety evaluation results. Results The Citrus grandis fructus immaturus is rich in flavonoids such as naringin and rhofolin. The levels of heavy metals, pesticide residues, and microbial indicators in the tested samples all met the relevant regulatory limits. Toxicological safety tests showed that Citrus grandis fructus immaturus exhibited no acute toxicity, genetic toxicity, or subacute toxicity. The no observed adverse effect level (NOAEL) was determined to be 10.0 g/kg body weight (BW). Based on the consumption patterns of Citrus grandis 'Tomentosa' in 19 cities in Guangdong, Huazhou city in Maoming was selected as a typical consumption area for the survey. Citrus grandis fructus immaturus was primarily consumed indirectly through methods such as soaking in water, boiling, or cooking in soups. The average daily intake in the typical consumption area was 1.19 g/day. No adverse reactions related to its consumption were reported. Conclusion For adults (excluding pregnant women, lactating women, and individuals under 18 years old), the potential health risks of consuming immature Citrus grandis fructus immaturus are low when the daily intake does not exceed 6.0 g.

Key words: Citrus grandis fructus immaturus, Eating, Safety assessment

中图分类号: 

  • R155.5