成都地区女性绝经后血清促甲状腺激素与代谢综合征相关性研究

doi:10.13217/j.scjpm.2019.0332

摘要/Abstract

摘要： 目的探讨成都地区绝经后女性代谢综合征（MS）发生情况及与血清促甲状腺激素（TSH）关系。方法采用分层整群抽样方法对成都地区绝经后女性进行调查,调查内容包括问卷调查、体格检查及血生化指标检测,对结果进行描述分析,并对MS与TSH相关性进行研究。结果 2018年共对成都地区绝经后女性3 512人进行调查,调查对象年龄40~74岁,文化程度以小学为主,占37.10%,家庭人均月收入以3 000~4 999元为主,占38.87%,以本地户籍为主,占76.74%,职业类型以文职为主,占58.68%,57.94%调查对象有MS家族史。检出MS 983例,发生率为27.99%。TSH与BMI、腰高比、空腹血糖、胰岛素抵抗指数、低密度脂蛋白胆固醇、甘油三酯呈正相关关系（r=0.860、0.820、0.819、0.680、0.718、0.588）,与高密度脂蛋白胆固醇呈负相关（r=-0.668）。多因素logistic回归分析结果显示TSH（OR=1.952）、低密度脂蛋白胆固醇（OR=1.861）、胰岛素抵抗指数（OR=1.850）值越高,绝经女性MS发生风险越高。结论成都地区绝经后女性MS发病率较高,TSH水平升高与MS发病密切相关。

关键词: 绝经女性, 血清促甲状腺激素, 代谢综合征

Abstract: Objective To investigate the status of metabolic syndrome （MS） in postmenopausal women in Chengdu and its relationship with serum thyroid stimulating hormone （TSH）. Methods A stratified cluster sampling method was used to investigate postmenopausal women in Chengdu. The study content included questionnaire survey, physical examination and detection of blood biochemical indicators. Data were described and analyzed, and the correlation between MS and TSH was studied. Results A total of 3 512 postmenopausal women aged 40-74 years were surveyed in 2018 in Chengdu. Of the participants, 37.10% had the education level at primary school, 38.87% had the per capita monthly household income ranging from 3 000 to 4 999 Yuan, 76.74% had local household registration, 58.68% had the occupation of civilian post, 57.94% had family history of MS. MS was detected in 983 cases, with an incidence rate of 27.99%. TSH was positively correlated with BMI, waist-to-height ratio, fasting blood glucose, insulin resistance index, low-density lipoprotein cholesterol （LDL-C）, and triglyceride （r=0.860, 0.820, 0.819, 0.680, 0.718, 0.588）, and negative with high-density lipoprotein cholesterol （r =-0.668）. Multivariate logistic regression analysis showed that the higher the values of TSH （OR=1.952）, LDL-C （OR=1.861）, and HOMA-IR （OR=1.850）, the higher the risk of MS in menopausal women. Conclusion The incidence of MS was higher in postmenopausal women in Chengdu. The increase of TSH level was closely related to the incidence of MS.

Key words: Menopause, Serum thyrotropin, Metabolic syndrome

中图分类号:

R195.4

黄杰, 傅爱军, 王娴, 李建红. 成都地区女性绝经后血清促甲状腺激素与代谢综合征相关性研究[J]. 华南预防医学, 2019, 45(4): 332-335.

HUANG Jie, FU Ai-jun, WANG Xian, LI Jian-hong. Relationship between serum thyrotropin and metabolic syndrome in postmenopausal women in Chengdu[J]. South China Journal of Preventive Medicine, 2019, 45(4): 332-335.

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