关键词: 孕早期, 孕妇, 甲状腺激素, 甲状腺过氧化物酶抗体, 游离甲状腺素, 促甲状腺激素

Abstract: Objective To analyze the abnormal thyroid hormone levels in early pregnant women and its influencing factors, so as to provide reference for the prevention and treatment of thyroid disease during pregnancy. Methods Taking the pregnant women of 10-12 weeks gestation from February 2020 to January 2021 in the obstetrics department of a hospital in Jinan as the research object, the thyroid hormone levels of the population were detected and the relevant data were collected. Descriptive epidemiological analysis method was used to analyze the abnormal thyroid hormone levels of early pregnant women, and univariate and multivariate analysis Methods were used to analyze its influencing factors. Results A total of 3 754 early pregnant women were enrolled, aged 20-42 years, 77.1% were 20-35 years old, 41.6% were 11-11⁺⁶ weeks gestation, 4.7% had a family history of thyroid disease, and those with a history of thyroid disease accounted for 2.9%. There were 179 cases of abnormal level of thyroid hormone, the abnormal rate was 4.8%, and hypothyroidism （87 cases, accounting for 48.6%） and subclinical hypothyroidism （38 cases, accounting for 21.2%） were more common. Multivariate Logistic regression analysis showed that pregnant women with anxiety （OR=2.026）, depression （OR=2.724）, a family history of thyroid disease （OR=3.438）, a history of thyroid disease （OR=4.043）, abnormal blood pressure （OR=1.931）, dyslipidemia （OR=1.539）, and abnormal blood glucose （OR=1.446） were more likely to have abnormal thyroid hormone levels in the early pregnancy, while pregnant women who consume iodized salt （OR=0.751） were less likely to have abnormal thyroid hormone levels in the early pregnancy. Conclusion The abnormal rate of thyroid hormone levels in early pregnant women is high, mainly hypothyroidism and subclinical hypothyroidism, which are affected by pregnant women’s anxiety, depression, family history of thyroid disease, history of thyroid disease, blood pressure, blood lipids, blood glucose, salt consumption, etc. The screening, monitoring and intervention of thyroid disease in pregnant women should be strengthened to ensure the safety of mothers and babies.

Key words: Early pregnancy, Pregnant women, Thyroid hormone, Thyroid peroxidase antibody, Free thyroxine, Thyroid-stimulating hormone