葡萄籽提取物、维生素E和硒的联合抗氧化作用研究

doi:10.13217/j.scjpm.2019.0301

华南预防医学 ›› 2019, Vol. 45 ›› Issue (4): 301-304.doi: 10.13217/j.scjpm.2019.0301

• 论著 • 下一篇

葡萄籽提取物、维生素E和硒的联合抗氧化作用研究

李志^1,2, 李文立², 黄俊明², 杨杏芬^1,2

1.南方医科大学公共卫生学院,广东广州 510515;
2. 广东省疾病预防控制中心

收稿日期:2019-04-15 出版日期:2019-08-20 发布日期:2019-08-28
通讯作者: 杨杏芬,E-mail: yangxingfen@21cn.com
作者简介:李志（1975—）,男,在职硕士研究生,主任医师,主要研究方向：营养与食品卫生

Antioxidant activity of grape seed extract, vitamin E and selenium

LI Zhi^1,2, LI Wen-li², HUANG Jun-ming², YANG Xing-fen^1,2

1.School of Public Health, Southern Medical University,Guangzhou 510515,China;
2.Guangdong Provincial Center for Disease Control and Prevention

Received:2019-04-15 Online:2019-08-20 Published:2019-08-28

摘要/Abstract

摘要： 目的探讨和分析葡萄籽提取物、维生素E和硒合理配伍后的复合制剂对人体抗氧化能力的影响。方法根据受试者的纳入标准筛选114名自愿参与者作为受试者,按试验前受试者血液中的丙二醛（MDA）、超氧化物歧化酶（SOD）活力和谷胱甘肽过氧化物酶（GSH-Px）活力情况分层后随机分为试验组和对照组,试验组受试者按每日服用量服用葡萄籽提取物、维生素E、硒复合制剂,对照组受试者按同等剂量服用安慰剂,连续服用3个月后,检测和分析2组受试者血液中MDA含量、SOD活力和GSH-Px活力的变化情况。结果本研究试验组和对照组各50人。2组受试者的年龄及性别构成差异均无统计学意义（均P>0.05）。试验结束后受试者精神状态、睡眠质量、饮食、大小便等均未发现明显异常,胸片、心电图、腹部B超检查结果也均未发现异常改变,均未出现不良反应。试验前2组受试者MDA含量、SOD活力和GSH-Px活力的差异均无统计学意义（均P>0.05）。试验后试验组MDA含量明显低于对照组,SOD活力和GSH-Px活力明显高于对照组（均P<0.05）。试验后试验组MDA含量下降率、SOD活力升高率和GSH-Px活力升高率明显高于对照组（均P<0.01）。结论葡萄籽提取物、维生素E、硒合理配伍后的复合制剂能够明显降低受试者的MDA含量、提高受试者的SOD活力和GSH-Px活力,葡萄籽提取物、维生素E和硒合理配伍后联合使用能够有效提升人体的抗氧化能力。

关键词: 葡萄籽提取物, 维生素E, 硒, 抗氧化

Abstract: Objective To evaluate effects of grape seed extract（GSE）, Vitamin E （VE） and selenium （Se） compound preparation on the antioxidant ability in human. Methods According to the inclusion criteria, 114 volunteer participants were selected as subjects. Be based on the levels of malondialdehyde （MDA）, superoxide dismutase （SOD） and glutathione peroxidase （GSH-Px） in blood, the Subjects were randomly divided into experimental group （n=50） and control group （n=50）. The experimental group was given GSE, VE and Se compound preparation for 3 months, and the control group was given placebo at the same dose. The MDA content, SOD activity and GSH-Px activity in blood of two groups were measured and analyzed. Results The experimental group and the control group each had 50 persons. There were no significant differences in age and gender between the two groups （P>0.05 for both）.After the experiment, no significant abnormalities were found in the mental state, sleep quality, diet, urine and feces of the subjects. No abnormal changes were found in the chest X-ray, electrocardiogram, and abdominal B-ultrasound examinations, and no adverse reactions occurred. Before the experiment, there was no significant differences in MDA content, SOD activity and GSH-Px activity between the two groups（P>0.05 for all）. After the experiment, the MDA content in the experimental group was significantly lower than that in the control group （P<0.05）; the activities of SOD and GSH-Px in the experimental group were significantly higher than those in the control group （P<0.05 for both）.Meanwhile, compared with the control group, the experimental group had higher decrease rate of MDA content,and the increase rates of SOD activity and GSH-Px activity （P<0.01 for all）. Conclusion The compound preparation of GSE, VE and Se could significantly reduce the MDA content,increase the SOD and GSH-Px activities of the subjects, and could effectively enhance the antioxidant capacity of the human body.

Key words: Grape seed extract, Vitamin E, Selenium, Antioxidation

中图分类号:

R151

李志, 李文立, 黄俊明, 杨杏芬. 葡萄籽提取物、维生素E和硒的联合抗氧化作用研究[J]. 华南预防医学, 2019, 45(4): 301-304.

LI Zhi, LI Wen-li, HUANG Jun-ming, YANG Xing-fen. Antioxidant activity of grape seed extract, vitamin E and selenium[J]. South China Journal of Preventive Medicine, 2019, 45(4): 301-304.

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葡萄籽提取物、维生素E和硒的联合抗氧化作用研究

Antioxidant activity of grape seed extract, vitamin E and selenium

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