四川省达州市育龄女性复发性流产影响因素分析

doi:10.12183/j.scjpm.2020.0481

摘要/Abstract

摘要： 目的探讨复发性流产的影响因素,为预防复发性流产制定预防措施提供依据。方法以2017年10月至2019年12月在四川省达州市某医院就诊的确诊为复发性流产患者为研究对象（病例组）,年龄相近且在同期同医院建档的过去未发生过自然流产的孕妇作为对照组,对2组人群的基本情况、饮食、患病情况、流产史、孕期情况、子宫发育情况和免疫指标进行比较分析。结果本研究共纳入复发性流产患者169例,对照组162人,2组人群年龄均为26~38岁。2组人群年龄、孕周分布差异均无统计学意义（均P>0.05）。多因素Logistic回归分析结果显示,孕前BMI≥27.0（OR=3.316）、生殖道感染（OR=2.449）、高泌乳素血症（OR=4.186）、黄体功能不全（OR=2.833）、甲减（OR=1.314）、PCOS（OR=1.727）、人工流产史≥3次（OR=3.719）、双角子宫（OR=1.843）、子宫过小（OR=2.541）、职业噪音暴露（OR=6.759）、抗磷脂抗体（OR=4.836）、抗核抗体（OR=3.452）、抗子宫内膜抗体（OR=2.949）、抗精子抗体（OR=2.170）、作息不规律（OR=5.930）者发生复发性流产风险更大,大专及以上（OR=0.321）、孕期补充叶酸（OR=0.692）者发生复发性流产的风险更低。结论复发性流产危险因素较多,应加强对育龄妇女生育相关知识的宣教工作,同时进行孕前检查,对于存在危险因素的育龄妇女应加强生殖健康相关项目的监测及检测,避免发生复发性流产。

关键词: 复发性流产, 危险因素, 预防, 影响因素

Abstract: Objective To explore the influencing factors of recurrent abortion, and to provide the basis for the prevention of recurrent abortion. Methods Patients with recurrent abortion in a hospital in Dazhou City, Sichuan Province from October 2017 to December 2019 were selected as the study group, pregnant women with similar age and without spontaneous abortion in the same hospital in the same period were selected as the control group. The basic conditions, diet,disease status, abortion history, pregnancy conditions, uterine development and immune indicators were compared between the two groups. Results A total of 169 patients with recurrent abortion were enrolled in study group, 162 were in the control group, and the age of both groups was 26-38 years old. Multivariate logistic regression analysis showed that pregnant women with pre-pregnancy BMI≥27.0 （OR=3.316）, reproductive tract infection （OR=2.449）, hyperprolactinemia （OR=4.186）, luteal insufficiency （OR=2.833）, hypothyroidism （OR=1.314）, PCOS （OR=1.727）, artificial abortion history ≥3 times （OR=3.719）, bicornate uterus （OR=1.843）, too small uterus （OR=2.541）, occupational noise exposure （OR=6.759）, anti-phospholipid antibody （OR=4.836）, antinuclear antibody （OR=3.452）, antiendometrium antibody （OR=2.949）, antisperm antibody （OR=2.170） and irregular work and rest （OR=5.930） had a higher risk of recurrent abortion, while those with college degree or above （OR=0.321） and folic acid supplementation during pregnancy （OR=0.692） had a lower risk of recurrent abortion. Conclusion There are many risk factors for recurrent abortion. We should strengthen the education of fertility-related knowledge and the pre-pregnancy examinations for women of childbearing period. For women of childbearing period with risk factors, we should strengthen the monitoring and detection of reproductive health related items to avoid recurrent abortion.

Key words: Recurrent abortion, Risk factor, Prevention, Influencing factor

中图分类号:

R173

唐固平, 李昭会, 陈丽融, 何红梅. 四川省达州市育龄女性复发性流产影响因素分析[J]. 华南预防医学, 2020, 46(5): 481-485.

TANG Gu-ping, LI Zhao-hui, CHEN Li-rong, HE Hong-mei. Influencing factors of recurrent abortion among women of childbearing period in Dazhou City, Sichuan Province[J]. South China Journal of Preventive Medicine, 2020, 46(5): 481-485.

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