Abstract: Objective To understand the situation of online public opinion since the outbreak of COVID-19 in Guangzhou, which provide a theoretical basis for the health administration departments to respond to online public opinion of public health emergency. Methods The data of online public opinion of the epidemic situation of COVID-19 in Guangzhou were collected and analyzed from the public opinion monitoring system of China Unicom from January 22 to April 21, 2020. Results A total of 2 389.69 million pieces of online public opinion were found in monitoring system, and the top three were Micro blog （63.73%）, Client （20.63%） and We Chat （7.79%）. The change trend of daily online public opinion information was basically similar to the number of new cases per day, and correlation was found （r=0.509; After the seven-day moving average, r=0.605）. Guangzhou, Wuhan, masks, Zhong Nan-shan, nurses, police, hospital, COVID-19, China, stores, SARS, epidemic, red cross society, foreigners, epidemic prevention and control were the high frequency keywords for this outbreak. Same as Guangdong Province（6.513 2 million）, a relatively high trend of the information about the epidemic situation of Guangzhou issued by Beijing（4.573 2 million）, Jiangsu Province（1.115 6 million）, Shandong Province（1.066 3 million） and Shanghai （1.039 4 million） was found. Conclusion Micro blog will still be an important platform for online public opinion monitoring. Grasping the situation of online public opinion in the period, taking countermeasures actively to guide the steady of public opinion, which can promote the disposal of public health emergency.

Key words: Guangzhou, COVID-19, Public opinion monitoring, Information