Abstract: Objective To analyze the case characteristics and etiological factors of premature coronary heart disease, to provide a reference for the prevention of premature coronary heart disease. Methods A total of 1 274 patients with premature coronary heart disease diagnosed and treated in two hospitals in Beijing from June 2020 to December 2021 were selected as the case objects, and healthy people with the age, gender, and body mass index of 1∶1 at the same time were selected as the control objects. The personal data of the two groups were investigated. The case characteristics of premature coronary heart disease were analyzed by descriptive analysis. The etiological factors of premature coronary heart disease were determined by univariate and multivariate Logistic regression analysis. Results In 1 274 patients with premature coronary heart disease, the male was more prominent than the female （62.09% vs. 37.91%）, the proportion of single vessel lesions was higher （51.10%）, and the lesion site was most common in the left anterior descending branch （53.69%）. Multivariate Logistic regression analysis showed that a family history of coronary heart disease （OR=2.812）, hypertension （OR=3.258）, diabetes （OR=1.691）, dyslipidemia （OR=3.184）, drinking （OR=1.774 ）, healthy diet （OR=0.773）, exercise habits （OR=0.209）, negative emotions （OR=2.212）, and health literacy （OR=0.693） were influencing factors of premature coronary heart disease. Conclusions The proportion of single vessel lesions in patients with premature coronary heart disease is high, and the lesion site is most common in the left anterior descending branch. The onset of the disease is affected by many factors. People with high-risk factors should be concerned, and targeted intervention measures should be taken to prevent and control the occurrence and development of premature coronary heart disease.

Key words: Premature coronary heart disease, Case characteristics, Risk factor