Abstract: Objective To explore the risk factors of premature acute coronary syndrome （ACS） in Zhengzhou. Methods Patients with ACS who were admitted to three A-grade hospitals in Zhengzhou from January 2020 to December 2020 were selected as the research objects, and they were divided into the premature ACS group and the non-premature ACS group. The descriptive analysis method was used to analyze the related indicators of the two groups, and univariate and multivariate analysis methods were used to analyze the influencing factors of premature ACS. Results There were no significant differences in gender, erythrocyte distribution width, platelet distribution width, uric acid, fasting blood glucose, and the number of coronary artery lesions between the two groups （all P > 0.05）; There were significant differences in overweight or obesity, smoking, family history of coronary heart disease, mean platelet volume, low-density lipoprotein cholesterol, and homocysteine between the two groups ??（P<0.05 or P<0.01）. Binary Logistic regression analysis showed that overweight or obesity （OR=1.442）, smoking （OR=3.012）, family history of coronary heart disease （OR=1.057）, high-level mean platelet volume （OR=1.993）, high-level low-density lipoprotein cholesterol （OR=2.942）, and high-level homocysteine ??（OR=3.522） were risk factors for premature ACS. Conclusion Family history of coronary heart disease, smoking, overweight, high-level low-density lipoprotein cholesterol, high-level homocysteine, and high-level mean platelet volume are risk factors for premature ACS.

Key words: Premature acute coronary syndrome, Low-density lipoprotein cholesterol, Risk factor