Abstract: Objective To analyze the correlation between body mass index （BMI） or waist circumference （WC） and the risk of positive thyroid autoantibody among physical examinees in Shanghai. Methods A total of 3 840 physical examinees in Shanghai were randomly selected by multi-stage cluster sampling method in the health examination center of Huadong Sanatorium from January to September 2019. Demographic data, physical examination, and laboratory indicators were collected. Multivariate Logistic regression and restricted cubic spline （RCS） were used to explore the correlation between BMI or WC and the risk of positive thyroid autoantibody. Results The incidence rate of positive thyroid autoantibody was 23.2% （892/3 840）. The result of RCS showed that there was linear dose-response relationship between continuous changes of BMI or WC and positive thyroid autoantibody （P_{for non-linearity} > 0.05）. Multivariate Logistic regression showed that obese people defined by BMI and WC had 1.82 and 2.20 times of the risk of positive thyroid autoantibody, respectively, compared with non-obese people. Simple abdominal obesity （OR=2.06） and compound obesity （OR=2.79） were independent risk factors for positive thyroid autoantibody. Conclusions The increase of BMI and WC in the physical examinees in Shanghai significantly increases the risk of positive thyroid autoantibody. Attention should be paid to the population with compound obesity and simple abdominal obesity, and a reasonable obesity management program should be developed to reduce visceral fat content.

Key words: Physical examinee, BMI, Waist circumference, Peripheral obesity, Abdominal obesity, Thyroid antibody