Abstract: Objective To analyze the occurrence, infection, transmission of relevant factors of hand-foot-mouth disease (HFMD) among scattered children. Methods Scattered children under 3 years and diagnosed with HFMD in Nanhai District of Foshan City in June 2012 were selected as case group according to the report of China Information System for Disease Control and Prevention. Scattered children at the similar ages and living in the same community with the case group but not subject to HFMD in the previous year were selected as control group. Epidemiological survey was conducted on the guardians of the children in both groups via standardized questionnaires. The content of the questionnaire included demographic situation, place of residence, travel, family and neighbors, disease diagnosis and treatment, contact history, activity history, and hygienic habit. Single-factor and multi-factor analyses on the risk factors of HFMD were carried out through chi-square test and logistic regression, respectively. Results The case group had 60 patients, 38 males and 22 females, mean age (1.37 ± 0.61) years. There were 101 children in the control group, 56 males and 45 females, mean age (1.30 ± 0.90) years. There were no statistically significant differences of gender and age between case group and control group. Multi-factor logistic regression analysis found that children with the following conditions were easier to get infected with HFMD: seldom washing hands after going out (OR=3.622), sharing hand towel (OR=30.086), visiting vaccination site in the past 2 weeks (OR=6.763), playing in the public activity place of the village in the past 2 weeks (OR=10.692), playing in enclosed play center for children in the mall frequently (OR=11.389), and the carer having low education level (OR=17.028). Conclusion It can be concluded that the scattered children’s infection with HFMD is closely related to the daily hygienic habits and the living environments. Parents shall try their best to eliminate or reduce all the risks when possible, and provide a safe and hygienic environment for the babies and children.