Abstract: Objective To study the pathogenic characteristics of pneumoconiosis in Zhongshan City and provide basis for prevention and control measures for pneumoconiosis. Methods Descriptive epidemiological method was used to analyze data collected from Chinese CDC occupational disease network reporting system from 2006 to 2013. Results A total of 136 cases of pneumoconiosis (all male) were reported in 8 years, of which 72 cases were in pneumoconiosis stage I (52.94%, 72/136), 46 cases in stage II (33.82%, 46/136), and 18 cases in stage III (13.24%,18/136); age of onset was (41.10±6.14) years (mean±SD) (range, 30.67-57.50 years); the dust exposure time was (5.78±3.13) years (range, 1.0-13.0 years). The main type of pneumoconiosis was silicosis (86.03%, 117/136). The main types of work relating pneumoconiosis were other types (42.65%, 58/136) and blaster (31.62%, 43/136). The industry distribution was mainly the non metal mining industry (44.12%, 60/136) and manufacturing (19.85%, 27/136). Small enterprises were the main type of business (70.59%, 96/136).Pneumoconiosis cases were distributed in 15 towns (districts), and the top three towns were Nanlang (36.03%, 49/136), Urban (19.12%, 26/136), and Sanxiang (17.65%, 24/136). The rate of pneumoconiosis complicated with tuberculosis was 3.68% (5/136). Conclusion Clinical features of pneumoconiosis were characterized by most cases with silicosis, onset at middle ages, and short length of service in Zhongshan City from 2006 to 2013. Small non metal mining and manufacturing industries were key enterprises for prevention and control of dust hazards.