Abstract: ObjectiveTo investigate the relationship between the quality of life, demographic characteristics, mental health and social support of AIDS patients.MethodsPatients diagnosed with HIV infection and receiving the antiretroviral therapy (ART) were recruited from January 2011 to August 2016 in Baoji City CDC using random sampling method. Participants were interviewed using the WHO quality of life scale (WHOQOL-HLV-BREF), AIDS symptom checklist (SCL-90) and social support rating scale (SSRS).ResultsA total of 48 patients aged from 19 - 61 years were investigated. Of all the participants, 77.08% (37/48) were males, 64.58% (31/48) were aged 31 - 50 years, 47.92% (23/48 were peasants and 31.25% (15/48) were workers, 68.75% (33/48) were married, 85.42% (41/48) had the educational level at high school (secondary school) or below, 45.83% (22 /48) had the average monthly income between 2 000 and 3 499 Yuan, and 47.92% (23/48) received ART less than 3 years. The total score of social support for the respondents was (23.93±1.81), and the detection rates of depression, anxiety, and psychotic disorders were 68.75%, 52.08%, and 35.42%, respectively. The score of psychotic factors were negatively correlated with quality of life (P< 0.05 or P＜0.01), and the scores of interpersonal sensitive,hostility and phobia factors were negatively correlated with the psychological domain of the quality of life (P<0.05 or P＜0.01). The scores of objective support and social support were positively correlated with the quality of life (psychology, spirit and total score) (P<0.05 or P＜0.01). ConclusionThe quality of life of patients with AIDS was closely related to their psychological health and social support. Pertinent measures should be taken to eliminate the mental problems of AIDS patients and strengthen various social support for the improvement of their quality of life.