Abstract: Objective To understand the status of quality of life（QOL），social support and in?fluencing factors of the compulsory drug abstainers，so as to provide scientific basis for improving their QOL treatment and education in Zhanjiang City. Methods A questionnaire survey was carried out by us?ing self ?compiled general information questionnaire，understanding social support scale and the World Health Organization Quality of Life（WHOQOL?BREF）to investigate drug addicts in a compulsory isola?tion detoxification center in Zhanjiang City. Data were analyzed by Student’s t?test，variance analysis and Pearson correlation analysis. Results A total of 488 male compulsory drug abstainers were investigated， with an average age of（39.32 ± 7.90）years. Of the subjects，47.75%（233/488）had stayed in the center for 6 to 12 months. The total score of perceived social support（52.12 ± 13.52），family support score（18.02 ± 5.45）and other support score（17.01 ± 4.91）of the compulsory drug abstainers were higher than those of domestic norm（all P＜0.01），but the scores of friend support（17.09 ± 5.07），physiological do?main（54.53 ± 15.09），psychological domain（53.20 ± 16.13），social relationship（55.67 ± 18.94）andenvironmental domain（49.14 ± 17.07）were less than those of the domestic norm（all P＜ 0.01）. The low?er the age of the respondents was，the higher the scores in the psychological and environmental domains would be；the higher the level of education was，the higher the scores in the physical，psychological，and environmental domains，perceived social support，family support，friend support，and other support would be；married subjects had higher scores of social relations and family support than those in unstable marriages；the respondents with jobs had higher scores of social relation and environmental domains than those without jobs；the higher the income was，the higher the scores of the physical，psychological，social relationship and environmental domains，and the perceived social support and family support would be； the longer the time in the compulsory detoxification was，the higher the scores of psychological，environ?mental，and other support would be（P＜0.05 for all）. Conclusion The QOL and perceived social sup?port level of compulsory drug abstainers were relatively low in Zhanjiang City. It is suggested that the gov?ernment，society and families should improve the social support for drug abstainers.