Abstract: Objective To describe and analyze the spatial and temporal?spatial epidemiological characteristics of human infection with avian influenza A（H7N9） virus in Foshan City from 2013 to 2017. Method Software Geoda v1.12 was used to analyze the global and local auto?correlation （GISA and LISA） of human infection with H7N9 avian influenza from December 2013 to September 2017 in Foshan City. SaTScan v9.4.3 was used for spatial?temporal scanning analysis. Results Before the restricted sale policy for live poultry was implemented， the GISA Moran’s I showed that the cases of human infection with avian influenza A（H7N9） occurred randomly during the 2013-2015 epidemic period. LISA Moran’s I showed that Dali Town in Nanhai District was a “High?high” clustering area （LISA Moran’s I ＝1.24， P＜0.05）. Spatial?temporal scanning statistics further showed that the epidemic peak of human infection with H7N9 avian influenza was observed in January 2014 in Dali Town， Nanhai District and Zumiao Street， Chancheng District， presenting a cluster occurrence （RR＝50.35， P＜0.01）. After implementing the restricted sale policy for live poultry， the GISA Moran’s I showed that the temporal epidemic characteristics of human infection with H7N9 avian influenza had been changed. The GISA Moran’s I showed that the H7N9 avian influenza epidemic in Foshan City was clustered from winter 2016 to spring 2017. LISA showed that Jiujiang Town in Naihai District was a “High?high” clustring area （LISA Moran’s I＝5.58， P＜0.01）. Spatial?temporal scanning showed that the epidemic in twons of Jiujiang and Xiqiao was serious from December 2016 to January 2017 （RR＝25.10，P＜0.05）. Conclusion The spatial clustering and spatio?temporal clustering of human infection with H7N9 avian influenza in Foshan City were obvious. The epidemic characteristics were different before and after the implementations of the restricted sale policy for live poultry. Before implementing the policy， cases were occurred randomly， but there was a clusterring tendency in densely populated area. After implementing the policy， case cluster area was mainly in the place where the restricted sale policy for live poultry was not implemented.