South China Journal of Preventive Medicine ›› 2019, Vol. 45 ›› Issue (4): 301-304.doi: 10.13217/j.scjpm.2019.0301

• Original Article •     Next Articles

Antioxidant activity of grape seed extract, vitamin E and selenium

LI Zhi1,2, LI Wen-li2, HUANG Jun-ming2, YANG Xing-fen1,2   

  1. 1.School of Public Health, Southern Medical University,Guangzhou 510515,China;
    2.Guangdong Provincial Center for Disease Control and Prevention
  • Received:2019-04-15 Online:2019-08-20 Published:2019-08-28

Abstract: Objective To evaluate effects of grape seed extract(GSE), Vitamin E (VE) and selenium (Se) compound preparation on the antioxidant ability in human. Methods According to the inclusion criteria, 114 volunteer participants were selected as subjects. Be based on the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in blood, the Subjects were randomly divided into experimental group (n=50) and control group (n=50). The experimental group was given GSE, VE and Se compound preparation for 3 months, and the control group was given placebo at the same dose. The MDA content, SOD activity and GSH-Px activity in blood of two groups were measured and analyzed. Results The experimental group and the control group each had 50 persons. There were no significant differences in age and gender between the two groups (P>0.05 for both).After the experiment, no significant abnormalities were found in the mental state, sleep quality, diet, urine and feces of the subjects. No abnormal changes were found in the chest X-ray, electrocardiogram, and abdominal B-ultrasound examinations, and no adverse reactions occurred. Before the experiment, there was no significant differences in MDA content, SOD activity and GSH-Px activity between the two groups(P>0.05 for all). After the experiment, the MDA content in the experimental group was significantly lower than that in the control group (P<0.05); the activities of SOD and GSH-Px in the experimental group were significantly higher than those in the control group (P<0.05 for both).Meanwhile, compared with the control group, the experimental group had higher decrease rate of MDA content,and the increase rates of SOD activity and GSH-Px activity (P<0.01 for all). Conclusion The compound preparation of GSE, VE and Se could significantly reduce the MDA content,increase the SOD and GSH-Px activities of the subjects, and could effectively enhance the antioxidant capacity of the human body.

Key words: Grape seed extract, Vitamin E, Selenium, Antioxidation

CLC Number: 

  • R151