Abstract: Objective To determine status of anxiety and depression in breast cancer patients after being discharged in community in Guangzhou and analyze their influencing factors. Methods Women who were not inpatient after being diagnosed with breast cancer and treated between 2010 and 2012 were recruited from 16 communities in Guangzhou using multistage cluster sampling for questionnaire survey. Contents of the questionnaire included demographic and clinical information, tumor family history, economic and psychological status, as well as self-rating anxiety scale (SAS) and self-rating depression scale （SDS）. The Chi square test and multivariate logistic regression were used for statistical analysis. Results A total of 245 questionnaires were recovered, with a recovery rate of 94.2% (245/260). The average age of patients was (57.2±11.7) years old. Of the patients, 50.6% (124/245) had the educational level of high school and above and 57.1% (140/245) were retirees. The average standard score of anxiety was (35.7±7.7), higher than the national norm (29.78±10.07) (P<0.01). The average crude score of depression was (38.7±9.2). The proportion of breast cancer patients with anxiety and depression were 28.6% (70/245) and 49.0% (120/245), respectively. Non-conditional logistic regression showed that 1-2 and more than 3 kinds of treatment side effects were risk factors of both anxiety and depression compared with no treatment side effects (anxiety: OR=21.9, 12.2; depression: OR=6.2, 4.8). A wish to obtain support from physicians was risk factor of anxiety relative to the one from family/friends (OR=2.2). However, more attention from physicians and family history of cancer were protective factors of depression for breast cancer patients comparing to those with less physician’s attention and without family history of cancer (both ORs=0.4). Conclusion The rates of anxiety and depression were higher in breast cancer patients in Guangzhou. We suggest to enhance the medical guidance and psychological intervention, reduce side effects of treatment, and improve the ability of patients to participate in social work, and increase communication between physicians and patients to reduce anxiety, depression, and other psychological problems.