Abstract: Objective To explore suicidal ideation and its relevant factors in people living with HIV/AIDS (PLWHA) and provide the basis for making AIDS care intervention countermeasure. Methods General condition questionnaire and Self-rating Idea of Suicide Scale ( SIOSS) were used in the survey. Face to face survey was conducted in PLWHA at AIDS VCT clinics, Panyu District, Guangzhou City. Multiple linear regression was used to analyze the data. Results Of 144 cases of PLWHA in the survey, 67.36% (97/144) were male, 32.64% (47/144) were female, and the average age was(36.9±10.8) years (mean±SD). 29.17%（42/144）have suicidal ideation. The rate of suicidal ideation was higher in those without job/unemployed（50.00%, 9/18）than those with job（26.29%, 33/126）, higher in those with technical/secondary school/high school（32.52%, 40/123）than those with college degree or above（9.52%, 2/21）, higher in persons living alone (58.33%, 7/12) than persons living with family (26.52%, 35/132), higher in those with the CD4 cell count ≤200 cells/μL (47.83%, 11/23) than those with the CD4 cell count >200 cells/μL (25.62%, 31/121), all P<0.05. Multivariate logistic regression showed that the employment status (adjusted OR:4.813, 95% CI: 1.250-18.526) and the resident manner (OR: 8.832, 95% CI: 1.330-58.661) were associated with the risk of suicidal ideation. Conclusion The prevalence of suicidal ideation was widespread among PLWHA. In the course of the follow-up care, effective and comprehensive support system should be established to improve the psychological status of PLWHA.