Abstract: ObjectiveTo analyze the infection status of key human parasites in Guangdong Province. MethodsIn accordance with the Survey Program of Infection Status of Key Human Parasitic Diseases issued by the Department of Health of Guangdong Province, 70 survey sites in 14 counties/cities/districts were sampled in Guangdong Province based on different geographic and economic situations, to investigate the human soil-borne nematodes and Clonorchis sinensis in 2010. Modified Kato-Katz thick smear method was used to detect intestinal worm eggs quantitatively and qualitatively. Children were examined by cellophane anal swab method. ResultsA total of 14 633 persons were examined by Modified Kato-Katz thick smear method and the total infection rate of the four species of parasites was 10.27%. The infection rates of ascaris, hookworm, trichuris and Clonorchis sinensis were 0.44%, 3.11%, 0.86%, and 6.19%, respectively. A total of 15 176 children aged 14 years and below were examined using the cellophane anal swab method. Of them, 3 048 cases (20.08%) were found to be infected with pinworm. The differences of positive rates of the 5 parasites among different geographical regions were statistically significant (P<0.05 or P<0.01). The positive rates of ascaris, trichuris, Clonorchis sinensis and pinworm among the regions in different economic levels, the positive rates of hookworm and Clonorchis sinensis among the populations with different ages, sexes and occupations, and the pinworm positive rates among different age groups, were all statistical difference (P<0.05 or P<0.01). ConclusionIn Guangdong Province, the infection rates of Clonorchis sinensis and hookworm in the population and that of pinworm in the children were still at relatively high level, but the crude infection rates of ascaris and trichuris were low. The characteristics of parasitic infections were significantly different among the different groups. The control measures should be made out for the high risk group of population according to different species of parasites.