Abstract: ObjectiveTo understand the current status of stress perception in MSM and analyze the influencing factors.MethodsFrom March to October 2015, men who have sex with men (MSM) in Mianyang City, Sichuan Province was recruited by snowball sampling method for questionnaire survey and serological detection. The survey contents included demographic characteristics, HIV/AIDS knowledge, preventive services, stress perception, stress source, sexual partners, and sexual behaviors. Single factor analysis of influencing factors was conducted using chi-square test and multi-factors were identified by multivariate unconditional logistic regression analysis.ResultsA total of 1 209 MSM were investigated, of whom 47.8% had stress perception. Of the stress sources, 38.4% (270/703) from interpersonal relationship, 34.1% (240/703) from financial condition, 33.0% (232/703) from the family, 28.4% (200/703)were from work, 26.2% (184/703) from health, 14.8% (104/703) from the sexual orientation,and 7.5%（53/703）from adaption. Of all the subjects, 65.4%(460/703) would actively deal with the stress, 31.9%(224/703) would seek social support, 9.5% (67/703) escape the negative impact of stress, 3.1% (22/703) passively wait, and 0.7% (5/703) take aggressive behavior. HIV infection rates were 4.0% (25/631) for those without stress perception and 8.3% (48/578) for those with it (P<0.01). The result of multi-factor analysis showed that the educational level, marital status, HIV/AIDS knowledge, looking for partner site, the number of anal sex in the last six months, the number of anal sex in the last one week, anal sex with or without protection in the last six months, and HIV infection were independent factors of stress perception (P＜0.05 or P＜0.01) .ConclusionThe stress perception of MSM in Mianyang was associated with the educational level, marital status, and HIV/AIDS high-risk behavior. Full attention should be paid to the negative effects of stress perception of the MSM and a lower stress social environment should be created actively to reduce the stress.